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HSPB2 Antikörper (PE)

HSPB2 Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal PE
Produktnummer ABIN2486045
  • Target Alle HSPB2 Antikörper anzeigen
    HSPB2 (Heat Shock 27kDa Protein 2 (HSPB2))
    Reaktivität
    • 43
    • 27
    • 27
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 58
    • 2
    Kaninchen
    Klonalität
    • 58
    • 2
    Polyklonal
    Konjugat
    • 26
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HSPB2 Antikörper ist konjugiert mit PE
    Applikation
    • 47
    • 19
    • 18
    • 14
    • 13
    • 13
    • 13
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~27 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein A Purified
    Immunogen
    Synthetic peptide
    Top Product
    Discover our top product HSPB2 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2486045 was sufficient for detection of MKBP in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.02 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    HSPB2 (Heat Shock 27kDa Protein 2 (HSPB2))
    Andere Bezeichnung
    HSPB2 (HSPB2 Produkte)
    Synonyme
    zgc:112532 antikoerper, HSP27 antikoerper, Hs.78846 antikoerper, LOH11CR1K antikoerper, MKBP antikoerper, 27kDa antikoerper, 2810021G24Rik antikoerper, heat shock protein family B (small) member 2 antikoerper, heat shock protein, alpha-crystallin-related, b2 antikoerper, heat shock protein 2 antikoerper, HSPB2 antikoerper, hspb2 antikoerper, Hspb2 antikoerper
    Hintergrund
    HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30 % sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSPs, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP's localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic (1). HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis (4).
    Gen-ID
    3316
    NCBI Accession
    NP_001532
    UniProt
    Q16082
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