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PDIA3 Antikörper (Alkaline Phosphatase (AP))

PDIA3 Reaktivität: Human WB, IHC, IF, IP, ICC Wirt: Maus Monoclonal Map-ERp57 Alkaline Phosphatase (AP)
Produktnummer ABIN2484404
  • Target Alle PDIA3 Antikörper anzeigen
    PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
    Reaktivität
    • 86
    • 38
    • 35
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 70
    • 28
    • 3
    Maus
    Klonalität
    • 66
    • 35
    Monoklonal
    Konjugat
    • 43
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PDIA3 Antikörper ist konjugiert mit Alkaline Phosphatase (AP)
    Applikation
    • 78
    • 31
    • 28
    • 27
    • 18
    • 16
    • 15
    • 13
    • 13
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    Detects ~57 kDa.
    Kreuzreaktivität
    Rind (Kuh), Hund, Meerschweinchen, Hamster, Human, Affe, Maus, Schwein, Kaninchen, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Human recombinant ERp57 (Grp58)
    Klon
    Map-ERp57
    Isotyp
    IgG1
    Top Product
    Discover our top product PDIA3 Primärantikörper
  • Applikationshinweise
    • WB (1:2000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.5 μg/ml of ABIN2484404 was sufficient for detection of ERp57 in 10 μg of heat shock Heal Lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
    Andere Bezeichnung
    ERp57 (PDIA3 Produkte)
    Synonyme
    ER60 antikoerper, ERp57 antikoerper, ERp60 antikoerper, ERp61 antikoerper, GRP57 antikoerper, GRP58 antikoerper, HsT17083 antikoerper, P58 antikoerper, PI-PLC antikoerper, grp-58 antikoerper, 58kDa antikoerper, Erp antikoerper, Grp58 antikoerper, PDI antikoerper, PDI-Q2 antikoerper, PLC[a] antikoerper, Plca antikoerper, 1 antikoerper, 25D3-membrane-associated antikoerper, sb:cb825 antikoerper, erp57 antikoerper, grp58 antikoerper, pdia3 antikoerper, protein disulfide isomerase family A member 3 antikoerper, protein disulfide-isomerase A3 antikoerper, protein disulfide isomerase associated 3 antikoerper, protein disulfide isomerase family A, member 3 antikoerper, protein disulfide isomerase family A member 3 S homeolog antikoerper, PDIA3 antikoerper, Tsp_10062 antikoerper, Pdia3 antikoerper, pdia3 antikoerper, pdia3.S antikoerper
    Hintergrund
    ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).
    Gen-ID
    2923
    NCBI Accession
    NP_005304
    UniProt
    P30101
    Pathways
    Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis
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