SCN9A Antikörper (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit) (AA 1751-1946) (Alkaline Phosphatase (AP))

Details for Product anti-SCN9A Antibody No. ABIN2483095, Anbieter: Anmelden zum Anzeigen
Antigen
  • SCN9A
  • DKFZp459G084
  • Nav1.7
  • PN1
  • mKIAA4197
  • Scn2a
  • ETHA
  • FEB3B
  • GEFSP7
  • NE-NA
  • NENA
  • SFNP
  • sodium channel, voltage-gated, type IX, alpha subunit
  • sodium voltage-gated channel alpha subunit 9
  • sodium channel protein type 9 subunit alpha
  • sodium channel, voltage-gated, type IX, alpha
  • SCN9A
  • LOC100016648
  • Scn9a
Epitop
AA 1751-1946, C-Term
40
35
8
3
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Hamster, Human, Maus, Ratte (Rattus)
94
59
56
17
4
3
3
2
1
1
1
1
Wirt
Maus
57
29
11
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser SCN9A Antikörper ist konjugiert mit Alkaline Phosphatase (AP)
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Antibody Array (AA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
70
52
50
40
39
25
23
17
13
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
Klon S68-6
Isotyp IgG1
Spezifität Detects ~230 kDa. No cross-reactivity against other Nav channels.
Reinigung Protein G Purified
Andere Bezeichnung Nav1.7 (SCN9A Antibody Abstract)
Hintergrund Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).
Gen-ID 6335
NCBI Accession NP_002968
UniProt Q15858
Forschungsgebiet Signaling, Metabolism
Applikationshinweise
  • WB (1:1000)
  • IHC (1:1000)
  • ICC/IF (1:100)
  • optimal dilutions for assays should be determined by the user.
Kommentare

1 μg/ml of SMC-314 was sufficient for detection of Nav1.7 in 10 μg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (Alkaline Phosphatase (AP)) (ABIN2483095) Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antib...
Western Blotting (WB) image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (Alkaline Phosphatase (AP)) (ABIN2483095) Western Blot analysis of hamster CHO cells showing detection of Nav1.7 Sodium Channel...
Immunohistochemistry (IHC) image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (Alkaline Phosphatase (AP)) (ABIN2483095) Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antib...
Immunohistochemistry (IHC) image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (Alkaline Phosphatase (AP)) (ABIN2483095) Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antib...
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