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Nav1.8 Antikörper (AA 1724-1956) (FITC)

SCN10A Reaktivität: Ratte IHC, WB, IF, ICC, AA Wirt: Maus Monoclonal S134 FITC
Produktnummer ABIN2483064
  • Target Alle Nav1.8 (SCN10A) Antikörper anzeigen
    Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))
    Bindungsspezifität
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1724-1956
    Reaktivität
    • 18
    • 16
    • 3
    • 1
    Ratte
    Wirt
    • 17
    • 14
    • 1
    • 1
    Maus
    Klonalität
    • 19
    • 14
    Monoklonal
    Konjugat
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nav1.8 Antikörper ist konjugiert mit FITC
    Applikation
    • 19
    • 19
    • 15
    • 12
    • 10
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Spezifität
    Detects ~220 kDa. No cross reactivity against other Nav channels.
    Kreuzreaktivität
    Human, Affe, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1724-1956 of rat Nav1.8
    Klon
    S134
    Isotyp
    IgG2a
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  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2483064 was sufficient for detection of Nav1.8 in 10 μg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))
    Andere Bezeichnung
    Nav1.8 (SCN10A Produkte)
    Synonyme
    Nav1.8 antikoerper, PN3 antikoerper, SNS antikoerper, hPN3 antikoerper, Na(V)1.8 antikoerper, sodium channel, voltage-gated, type X, alpha antikoerper, sodium voltage-gated channel alpha subunit 10 antikoerper, Scn10a antikoerper, SCN10A antikoerper
    Hintergrund
    Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
    Gen-ID
    29571
    NCBI Accession
    NP_058943
    UniProt
    Q62968
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