MLST8 Antikörper (MTOR Associated Protein, LST8 Homolog (S. Cerevisiae)) (AA 150-200)

Details for Product anti-MLST8 Antibody No. ABIN2470104, Anbieter: Anmelden zum Anzeigen
Antigen
  • gbl
  • lts8
  • GBL
  • GbetaL
  • LST8
  • POP3
  • WAT1
  • 0610033N12Rik
  • AA409454
  • AI505104
  • AI851821
  • Gbl
  • fi37e04
  • wu:fi37e04
  • zgc:55455
  • zgc:85668
  • MTOR associated protein, LST8 homolog L homeolog
  • MTOR associated protein, LST8 homolog
  • MTOR associated protein, LST8 homolog (S. cerevisiae)
  • mlst8.L
  • MLST8
  • Mlst8
  • mlst8
Epitop
AA 150-200
25
14
11
10
9
6
4
3
3
3
2
2
2
2
1
1
Reaktivität
Huhn, Schimpanse, Rind (Kuh), Hund, Human, Makake, Affe, Maus, Ratte (Rattus)
118
64
46
9
8
7
4
4
4
3
3
3
3
2
2
2
2
1
1
1
Wirt
Kaninchen
111
18
2
Klonalität
Polyklonal
Konjugat
Dieser MLST8 Antikörper ist unkonjugiert
7
7
6
5
5
5
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
110
44
32
17
13
9
5
3
2
2
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen GBL antibody was raised against amino acids 150 - 200 of GBL (Human).
Reinigung Protein G Column
Andere Bezeichnung GBL (MLST8 Antibody Abstract)
Hintergrund LST8, a 36-40 kDa intracellular protein, is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin-receptor activation including insulin-stimulated glucose transport and glycogen synthesis. Northern Blot analysis detected a ubiquitous expression of LST8 with highest expression in brain and testis. Part of the mammalian target of rapamycin complex 1 (mTORC1), which is composed of mTOR, regulatory associated protein of mTOR (Raptor), mammalian LST8/G-protein beta-subunit like protein (mLST8/GbetaL) and the recently identified partner PRAS40. This complex is characterized by the classic features of mTOR by functioning as a nutrient/energy/redox sensor and controlling protein synthesis. The activity of this complex is stimulated by insulin, growth factors, serum, phosphatidic acid, amino acids (particularly leucine), and oxidative stress.
Gen-ID 64223
UniProt Q9BVC4
Pathways PI3K-Akt Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Autophagie, CXCR4-mediated Signaling Events
Applikationshinweise GBL antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer PBS, 0.2 % gelatin, 0.05 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung As with all antibodies avoid freeze/thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung GBL antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-MTOR Associated Protein, LST8 Homolog (S. Cerevisiae) (MLST8) (AA 150-200) antibody (ABIN2470104) anti-MTOR Associated Protein, LST8 Homolog (S. Cerevisiae) (MLST8) (AA 150-200) antibody
Haben Sie etwas anderes gesucht?