GLE1 Antikörper

Produktnummer ABIN2459776

Produktdetails anti-GLE1 Antikörper

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GLE1.

Anwendungsinformationen

Applikationshinweise: GLE1 antibody can be used for detection of GLE1 by ELISA at 1:1562500. GLE1 antibody can be used for detection of GLE1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GLE1 antibody at -20 °C.

Details zu GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Andere Bezeichnung: GLE1 (GLE1 Produkte)

Synonyme: Dmel\\CG14749 antikoerper, GLE1 antikoerper, GLE1L antikoerper, LCCS antikoerper, LCCS1 antikoerper, hGLE1 antikoerper, Gle1l antikoerper, 4933405K21Rik antikoerper, AA553313 antikoerper, CG14749 gene product from transcript CG14749-RA antikoerper, nucleoporin GLE1 antikoerper, RNA export factor Gle1 antikoerper, GLE1, RNA export mediator antikoerper, GLE1 RNA export mediator antikoerper, GLE1 RNA export mediator (yeast) antikoerper, CG14749 antikoerper, CpipJ_CPIJ014147 antikoerper, SJAG_03847 antikoerper, GLE1 antikoerper, Gle1 antikoerper

Hintergrund: GLE1 is a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly (A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly (A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm.This gene encodes a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly (A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly (A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 75 kDa

Gen-ID: 2733

NCBI Accession: NP_001490

UniProt: Q53GS7