PILRB Antikörper

Produktnummer ABIN2459063

Produktdetails anti-PILRB Antikörper

Target: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PILRB Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PILRB.

Anwendungsinformationen

Applikationshinweise: PILRB antibody can be used for detection of PILRB by ELISA at 1:312500. PILRB antibody can be used for detection of PILRB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PILRB antibody at -20 °C.

Details zu PILRB

Target: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Andere Bezeichnung: PILRB (PILRB Produkte)

Synonyme: FDFACT1 antikoerper, FDFACT2 antikoerper, FDFACT antikoerper, Fdact antikoerper, Pilrb antikoerper, paired immunoglobin-like type 2 receptor beta antikoerper, paired immunoglobin-like type 2 receptor beta 1 antikoerper, PILRB antikoerper, Pilrb1 antikoerper, Pilrb antikoerper

Hintergrund: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.

Molekulargewicht: 23 kDa

Gen-ID: 29990

NCBI Accession: NP_038468

UniProt: Q9UKJ0