MNDA Antikörper

Produktnummer ABIN2458298

Produktdetails anti-MNDA Antikörper

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MNDA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MNDA.

Anwendungsinformationen

Applikationshinweise: MNDA antibody can be used for detection of MNDA by ELISA at 1:1562500. MNDA antibody can be used for detection of MNDA by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MNDA antibody at -20 °C.

Details zu MNDA

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Andere Bezeichnung: MNDA (MNDA Produkte)

Synonyme: PYHIN3 antikoerper, A730048F03 antikoerper, Ifi205b antikoerper, myeloid cell nuclear differentiation antigen antikoerper, interferon activated gene 211 antikoerper, MNDA antikoerper, Ifi211 antikoerper

Hintergrund: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage.MNDA may act as a transcriptional activator/repressor in the myeloid lineage. It plays a role in the granulocyte/monocyte cell-specific response to interferon. MNDA stimulates the DNA binding of the transcriptional repressor protein YY1.The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molekulargewicht: 46 kDa

Gen-ID: 4332

NCBI Accession: NP_002423

UniProt: P41218