SUMO2/3 Antikörper (full length)

Produktnummer ABIN2452139

Produktdetails anti-SUMO2/3 Antikörper

Target: SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))

Bindungsspezifität: full length

Reaktivität: Human, Maus, Ratte

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser SUMO2/3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Specific to SUMO2 and SUMO3 of human, simian, mouse, hamster and rat. Does not react with SUMO1. This antibody recognizes both SUMO2 and SUMO3, but not SUMO1.

Kreuzreaktivität (Details): Not tested for other species

Aufreinigung: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Sterilität: Sterile filtered

Immunogen: Recombinant GST-fused human SUMO3 (full length)

Klon: 3H12

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: 1. Western blotting: 1/1,000
2. Immunocytochemistry/Immunofluorescence staining: 1/100~1/500
3. Immunohistochemistry,frozen section: 1/100~1/500
4. ELISA (Assay dependent concentration)
Other applications have not been tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS (x1), 50 % glycerol. Azide and carrier free.

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Upon arrival centrifuge briefly and store at -20 C.

Referenzen für anti-SUMO2/3 Antikörper (ABIN2452139)

Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

Details zu SUMO2/3

Target: SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))

Andere Bezeichnung: SUMO2/3 (SUMO2/3 Produkte)

Hintergrund: SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 and 3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.

Molekulargewicht: 10,871 Da with 95 AA, 11,637 Da with 103 AA

UniProt: P61956, P55854