PRNP Antikörper

Produktnummer ABIN2452081

Produktdetails anti-PRNP Antikörper

Target: PRNP (Prion Protein (PRNP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRNP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): Does not react with mouse Prion. Not tested with other species

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13.

Klon: 7A1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1) Western blotting: ~0. 5 g/mL
2) ELISA
Other applications have not been tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Upon arrival centrifuge briefly, aliquot and store at -20 C

Referenzen für anti-PRNP Antikörper (ABIN2452081)

Sakudo, Nakamura, Tsuji, Ikuta: "GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity." in: International journal of molecular medicine, Vol. 21, Issue 2, pp. 217-22, (2008) (PubMed).

Details zu PRNP

Target: PRNP (Prion Protein (PRNP))

Andere Bezeichnung: Prion Protein (PRNP Produkte)

Synonyme: ASCR antikoerper, AltPrP antikoerper, CD230 antikoerper, CJD antikoerper, GSS antikoerper, KURU antikoerper, PRIP antikoerper, PrP antikoerper, PrP27-30 antikoerper, PrP33-35C antikoerper, PrPc antikoerper, p27-30 antikoerper, Prn antikoerper, Prn-p antikoerper, prp antikoerper, cjd antikoerper, prion antikoerper, prp(c) antikoerper, MGC84114 antikoerper, PRP antikoerper, PRPC antikoerper, Prp antikoerper, SIP antikoerper, PRNP antikoerper, AA960666 antikoerper, AI325101 antikoerper, PrP antikoerper, PrPC antikoerper, PrPSc antikoerper, Prn-i antikoerper, Sinc antikoerper, prP27-30 antikoerper, prP33-35C antikoerper, PrP-1 antikoerper, PrP1 antikoerper, prnprs1 antikoerper, stPrP-1 antikoerper, zgc:123004 antikoerper, prion protein antikoerper, prion protein S homeolog antikoerper, prion protein b antikoerper, PRNP antikoerper, Prnp antikoerper, prnp.S antikoerper, prnpb antikoerper

Hintergrund: Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPPC proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their. Mature PrP protein in human consists of 209 amino acids. Several forms exist, one cell surface form anchored via and two forms, which are responsible for appearance of multiple bands in SDS-PAGE.

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation