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CD14 Molecule (CD14) Antikörper
| Antigen | CD14 Molecule (CD14) |
| Synonyme | CD14 |
| Klonalität | Monoklonal (Tük4) |
| Wirt |
Alternativen Maus |
| Reaktivität |
Alternativen Rind (Kuh) |
| Applikation |
Alternativen Enzyme Immunoassay (EIA), Durchflusszytometrie (FACS), Funktionale Studien (Func), Western Blot (WB)
|
| Produktnummer | ABIN238505 |
| Menge | 0.5 mg (1.0 mg/ml) (Varianten) |
| Preis | 570,00 € Zzgl. Versandkosten €20,00 und MWSt |
| Lieferung nach |
|
| Verfügbarkeit | Lieferung in 7 bis 10 Werktagen |
Produktbeschreibung
| Produktmerkmale | Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein |
| Weitere Bezeichnung | CD14 |
| Swiss-Prot | P08571 |
| Immunogen | Proprietary peptide sequence. |
| Kreuzreaktivität | Rind (Kuh), Hund, Katze, Ziege, Human, Affe, Schwein, Kaninchen, Schaf |
| Isotyp | IgG2a (Passende Sekundärantikörper) |
| Klon | Tük4 |
| Beschreibung | CD14 is a single copy gene encoding 2 protein forms: a 50 to 55 kDaglycosylphosphatidylinositol anchored membrane protein (mCD14) and a monocyte or liverderived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical forlipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivityto cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectiousdiseases and high mortality in gram negative shock. CD14 also appears to be involved inclearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes. |
| Spezifität | The antibody detects CD14 (low endotoxin) cell surface antigen, which is expressedstrongly by most peripheral blood monocytes and weakly on granulocytes. Species: Human. Cross recats with Cynomolgus monkey, Pig, Bovine, Sheep, Goat, Dog,Cat, Mink and Rabbit. Others not tested. Add. Information: Endotoxin level < 0. 01 Eu/µg |
Anwendungen
| Applikationshinweise | ELISA. Western blot. Flow Cytometry (1/100). Functional assay. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
| Konzentration | 1.0 mg/ml |
| Reinigung | Aff - Purified |
| Buffer | PBS |
| Lagerung | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Forschungsgebiet | Stammzellen, Angeborene Immunität, Hämopoetische Vorläufer, Hämatopoetische Stammzellen, CD Antigene, Oberflächenrezeptoren der Immunzellen , Apoptose/Nekrose, Immunologie, Inflammation |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
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