SOS1 Antikörper (Son of Sevenless Homolog 1 (Drosophila))

Details for Product anti-SOS1 Antibody No. ABIN238504, Anbieter: Anmelden zum Anzeigen
Antigen
  • GF1
  • GGF1
  • GINGF
  • HGF
  • NS4
  • 4430401P03Rik
  • 9630010N06
  • AI449023
  • son of sevenless homolog 1 (Drosophila)
  • Son of sevenless homolog 1 (Drosophila)
  • SOS1
  • Sos1
Reaktivität
Human, Maus
52
33
13
8
8
7
7
6
5
4
3
3
1
1
Wirt
Maus
32
21
7
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser SOS1 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
43
21
20
13
8
6
3
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
Klon SOS-1
Isotyp IgG1
Spezifität The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.
Produktmerkmale Synonyms: SOS-1, Son of sevenless homolog 1
Reinigung Protein A affinity chromatography.
Andere Bezeichnung SOS1 (SOS1 Antibody Abstract)
Hintergrund The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.Synonyms: SOS-1, Son of sevenless homolog 1
Gen-ID 6654
UniProt Q07889
Forschungsgebiet Cancer
Pathways RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor
Applikationshinweise Western Blotting under reducing conditions (1 μg/mL): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer PBS, pH 7.4 with 15 mM sodium azide as preservative.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (ABIN238504) anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody
Immunofluorescence (IF) image for anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (ABIN238504) anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (Image 2)
Immunofluorescence (IF) image for anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (ABIN238504) anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (Image 3)
Allgemeine Veröffentlichungen Freedman, Sondermann, Friedland, Kortemme, Bar-Sagi, Marqusee, Kuriyan: "A Ras-induced conformational switch in the Ras activator Son of sevenless." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 45, pp. 16692-7, 2006 (PubMed).

Yang, Bashaw: "Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline." in: Neuron, Vol. 52, Issue 4, pp. 595-607, 2006 (PubMed).

Silver, Chen, Doyon, Zink, Rebay: "New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function." in: Genesis (New York, N.Y. : 2000), Vol. 39, Issue 4, pp. 263-72, 2004 (PubMed).

Innocenti, Tenca, Frittoli, Faretta, Tocchetti, Di Fiore, Scita: "Mechanisms through which Sos-1 coordinates the activation of Ras and Rac." in: The Journal of cell biology, Vol. 156, Issue 1, pp. 125-36, 2002 (PubMed).

Tian, Feig: "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47248-56, 2001 (PubMed).

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