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	+49 (0)241 95 163 153
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CD8a Molecule (CD8A) Antikörper (Biotin)

Antigen	CD8a Molecule (CD8A)
Synonyme	CD8, MAL, p32, Leu2, Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, MGC136643, zgc:136643, cd8, LOC100136450
Klonalität	Monoklonal (MEM-87)
Wirt	Alternativen Maus Maus (430), Ratte (139), Kaninchen (92)
Reaktivität	Alternativen Human Human (356), Maus (143), Ratte (Rattus) (68), Huhn (33), Katze (27), Affe (23), Schwein (18), Hund (16), Rind (Kuh) (13), Schaf (13), Kaninchen (10), Pferd (8), Meerschweinchen (6), Pute (5), Ziege (4), Vogel (1), Ente (1)
Konjugat	Alternativen Biotin FITC (108), Biotin (66), PE (61), APC (23), Cy5 (12), RPE (12), PE,Cy7 (8), PE,Cy5 (5), SPRD (5), Alexa Fluor 488 (4), HRP (4), PE,Cy5.5 (4), APC,Cy7 (3), Alexa Flour 488 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5,PE (3), Cy5.5 (3), Cy7 (3), Gold (3), PE,Cy3 (3), Pacific Blue (3), RBITC (3), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 700 (2), PE,Texas Red (TR) (2), PerCP (2), APC,Cy5.5 (1), Cy5.5,PE (1), Cy7,PE (1), DY647 (1), PE,DY590 (1), PE,DY647 (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1), RPE,Cy5 (1), RPE,Cy5.5 (1), RPE,Cy7 (1)
Applikation	Alternativen Durchflusszytometrie (FACS) Durchflusszytometrie (FACS) (524), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (196), Immunpräzipitation (IP) (121), Immunhistochemie (Paraffinschnitte) (IHC (p)) (66), Immunfluoreszenz (IF) (62), Western Blot (WB) (54), ELISA (33), Immunhistochemie (IHC) (22), Immunzytochemie (ICC) (16), Funktionale Studien (Func) (9), Blockierende Antikörper (Inhibition) (6), Zytotoxizitätstest (CyTox) (6), Enzyme Immunoassay (EIA) (6), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (6), Immunoelectron Microscopy (IEM) (3), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1), Radioimmunoassay (RIA) (1), To be determined by user (TBD) (1)

Produktnummer	ABIN238479
Menge	0.1 mg (1.0 mg/ml)
Preis	230,00 € Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit	Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen zurück nach oben

Produktmerkmale	Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain
Weitere Bezeichnung	CD8
Gen-ID	925
Swiss-Prot	P01732
Immunogen	Leukocytes of a patient suffering from LGL Type Leukemia.
Kreuzreaktivität	Human
Isotyp	IgG1
Klon	MEM-87
Beschreibung	The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as αβ heterodimer onmajority of MHC I-restricted conventional T cells and thymocytes and as αα homodimer onsubsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8β level on T cell surface seems to be an important mechanism to controltheir effector function. Assembly of CD8 α-β but not α-α dimers is connected with formationor localization to the lipid rafts. Recruiting triggered TCR complexes to these membranemicrodomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting thefunctional diversity of the TCR signaling.
Spezifität	The antibody MEM-87 recognizes CD8, a cell surface glycoprotein found on most cytotoxicT lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8is a disulfide-linked dimer and exists as a CD8α homodimer or CD8α/β heterodimer (eachmonomer approx. 32-34 kDa). Species: Human. Others not tested.

Anwendungen
Alternativen zurück nach oben

Applikationshinweise	this biotinylated antibody is suitable for indirect Immunofluorescence analysis by FlowCytometry: 5-10 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Konzentration	1.0 mg/ml
Buffer	PBS, pH 7.4 containing 15 mM sodium azide as preservative.Label: Conjugated with Biotin-LC-NHS under optimum conditions.The reagent is free of unconjugated biotin.
Lagerung	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Forschungsgebiet	Immunologie, Adaptive Immunität, Hämopoetische Vorläufer, CD Antigene, Oberflächenrezeptoren der Immunzellen
Beschränkungen	Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen zurück nach oben

Alternativen zu Antigen "CD8a Molecule (CD8A)", Typ "Antikörper" finden

Wirte	Maus (430), Ratte (139), Kaninchen (92)
Reaktivitäten	Human (356), Maus (143), Ratte (Rattus) (68), Huhn (33), Katze (27), Affe (23), Schwein (18), Hund (16), Rind (Kuh) (13), Schaf (13), Kaninchen (10), Pferd (8), Meerschweinchen (6), Pute (5), Ziege (4), Vogel (1), Ente (1)
Applikationen	Durchflusszytometrie (FACS) (524), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (196), Immunpräzipitation (IP) (121), Immunhistochemie (Paraffinschnitte) (IHC (p)) (66), Immunfluoreszenz (IF) (62), Western Blot (WB) (54), ELISA (33), Immunhistochemie (IHC) (22), Immunzytochemie (ICC) (16), Funktionale Studien (Func) (9), Blockierende Antikörper (Inhibition) (6), Zytotoxizitätstest (CyTox) (6), Enzyme Immunoassay (EIA) (6), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (6), Immunoelectron Microscopy (IEM) (3), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1), Radioimmunoassay (RIA) (1), To be determined by user (TBD) (1)
Konjugate	FITC (108), Biotin (66), PE (61), APC (23), Cy5 (12), RPE (12), PE,Cy7 (8), PE,Cy5 (5), SPRD (5), Alexa Fluor 488 (4), HRP (4), PE,Cy5.5 (4), APC,Cy7 (3), Alexa Flour 488 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5,PE (3), Cy5.5 (3), Cy7 (3), Gold (3), PE,Cy3 (3), Pacific Blue (3), RBITC (3), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 700 (2), PE,Texas Red (TR) (2), PerCP (2), APC,Cy5.5 (1), Cy5.5,PE (1), Cy7,PE (1), DY647 (1), PE,DY590 (1), PE,DY647 (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1), RPE,Cy5 (1), RPE,Cy5.5 (1), RPE,Cy7 (1)
Epitope	C-Term (1), N-Term (1)