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Endoglin Antikörper

ENG Reaktivität: Human, Schwein WB, FACS, IF, IHC (fro) Wirt: Maus Monoclonal MEM-229 unconjugated
Produktnummer ABIN238459
  • Target Alle Endoglin (ENG) Antikörper anzeigen
    Endoglin (ENG)
    Reaktivität
    • 177
    • 67
    • 44
    • 17
    • 9
    • 3
    • 2
    • 1
    Human, Schwein
    Wirt
    • 107
    • 92
    • 21
    • 1
    • 1
    Maus
    Klonalität
    • 114
    • 107
    • 1
    Monoklonal
    Konjugat
    • 92
    • 28
    • 26
    • 26
    • 15
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Endoglin Antikörper ist unkonjugiert
    Applikation
    • 152
    • 133
    • 62
    • 58
    • 37
    • 20
    • 19
    • 15
    • 14
    • 13
    • 13
    • 7
    • 5
    • 5
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    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Porcine.
    Produktmerkmale
    Synonyms: ENG, END, HHT1, ORW, ORW1
    Aufreinigung
    Protein-A Affinity Chromatography
    Immunogen
    Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.
    Klon
    MEM-229
    Isotyp
    IgG2a
    Top Product
    Discover our top product ENG Primärantikörper
  • Applikationshinweise
    Flow Cytometry: 10 μg/mLPositive Control: Kg1 Human acute myelogenous leukemia cell lineWestern Blotting (Non-Reducing Conditions).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH ~7.4, 15 mM Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Haltbarkeit
    12 months
  • Koch, Staffler, Hüttinger, Hilgert, Prager, Cerný, Steinlein, Majdic, Horejsí, Stockinger: "T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density." in: International immunology, Vol. 11, Issue 5, pp. 777-86, (1999) (PubMed).

  • Target
    Endoglin (ENG)
    Andere Bezeichnung
    CD105 / Endoglin (ENG Produkte)
    Synonyme
    ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper
    Hintergrund
    CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1
    UniProt
    P17813
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