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Integrin beta 2 (ITGB2) (Activation Site) Antikörper
| Antigen | Integrin beta 2 (ITGB2) |
| Synonyme | 2E6, LAD, Cd18, Lfa1, MF17, LCAMB, AI528527, CD18, MFI7, LFA-1, MAC-1, CD61, GP3A, GPIIIa, INGRB3, MGC159221, MGC159223, ITGB2, integrin, ITGB3, MGC116306 |
| Epitope |
 Alternativen Activation Site |
| Klonalität | Monoklonal (MEM-148) |
| Wirt |
Alternativen Maus |
| Reaktivität |
Alternativen Human |
| Applikation |
Alternativen Durchflusszytometrie (FACS), Funktionale Studien (Func), Immunpräzipitation (IP), Western Blot (WB)
|
| Produktnummer | ABIN238447 |
| Menge | 0.1 mg (1.0 mg/ml) |
| Preis | 200,00 € Zzgl. Versandkosten €20,00 und MWSt |
| Lieferung nach |
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| Verfügbarkeit | Lieferung in 7 bis 10 Werktagen |
Produktbeschreibung
| Produktmerkmale | Synonyms: Integrin beta-2, MFI7, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunitbeta, Complement receptor C3 subunit beta |
| Weitere Bezeichnung | CD18 / ITGB2 |
| Swiss-Prot | P05107 |
| Immunogen | Peripheral blood mononuclear cells. |
| Kreuzreaktivität | Human |
| Isotyp | IgG1 (Passende Sekundärantikörper) |
| Klon | MEM-148 |
| Beschreibung | CD18, integrin β2 subunit, forms heterodimers with four types of CD11 molecule toconstitute leukocyte (β2) integrins: αLβ2 (CD11a/CD18, LFA-1), αMβ2 (CD11b/CD18, Mac-1,CR3), αXβ2 (CD11c/CD18) and αDβ2 (CD11d/CD18). In most cases, the response mediatedby the integrin is a composite of the functions of its individual subunits. These integrinsare essential for proper leukocyte migration, mediating intercellular contacts. Absence ofCD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leadsto the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia(Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediatedcytolysis. |
| Spezifität | The antibody MEM-148 recognizes the epitope exposed on free human CD18 chainsunassociated with CD11 as well as on high-affinity state of LFA-1. CD18 (integrin β2 subunit,β2 integrin) is a 90-95 kDa type I transmembrane protein expressed on all leukocytes. Negative Species: Porcine. Species Reactivity: Tested: Human. |
Anwendungen
| Applikationshinweise | Flow Cytometry: This antibody is excellent marker of activated myeloid cells. Immunoprecipitation. Western Blotting (Non-reducing conditions). Functional Application: The antibody MEM-148 induces homotypic cell aggregation andhigh-affinity LFA-1 conformation in resting leukocytes. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
| Konzentration | 1.0 mg/ml |
| Reinigung | Azide Free |
| Buffer | PBS, pH 7.4 without preservatives |
| Lagerung | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles. Shelf life: One year from despatch. |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
Alternativen
Alternativen zu Antigen "Integrin beta 2 (ITGB2)", Typ "Antikörper" finden
| Wirte | Maus (88), Ratte (50), Kaninchen (8), Huhn (1) |
| Reaktivitäten | Human (71), Ratte (Rattus) (33), Maus (31), Hund (16), Schwein (7), Rind (Kuh) (4), Kaninchen (3) |
| Applikationen | Durchflusszytometrie (FACS) (133), Immunpräzipitation (IP) (69), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (55), Western Blot (WB) (36), Immunhistochemie (Paraffinschnitte) (IHC (p)) (17), Funktionale Studien (Func) (8), Immunfluoreszenz (IF) (4), Enzyme Immunoassay (EIA) (3), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1) |
| Konjugate | FITC (24), PE (16), Biotin (15), APC (2) |
| Epitope | pSer745 (1) |
