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Antikörper
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anti-Linker For Activation of T Cells (LAT) Antikörper
Linker For Activation of T Cells (LAT) Antikörper
| Antigen |
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| Synonyme |
LAT1, pp36, MGC108666, LAT, MGC157208, lat |
| Klonalität |
Monoklonal (LAT-1D1) |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Immunfluoreszenz (IF), Immunpräzipitation (IP), Western Blot (WB)
Western Blot (WB) (47), Immunpräzipitation (IP) (20), Durchflusszytometrie (FACS) (18), Immunhistochemie (Paraffinschnitte) (IHC (p)) (12), ELISA (9), Enzyme Immunoassay (EIA) (8), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (5), Immunhistochemie (IHC) (3), Immunzytochemie (ICC) (2), Immunfluoreszenz (IF) (2), Dot Blot (Dot) (1)
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| Produktnummer |
ABIN238425 |
| Menge |
0.1 mg (1.0 mg/ml) |
| Preis |
210,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Produktmerkmale
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Synonyms: pp36, p36-38, 36 kDa Phospho-Tyrosine Adapter Protein, Linker For Activation of T-CellsFamily Member 1
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Weitere Bezeichnung
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LAT
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Gen-ID
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27040
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Swiss-Prot
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O43561
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Immunogen
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Recombinant rat LAT.
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Kreuzreaktivität
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Maus, Ratte (Rattus)
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Isotyp
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IgG2a (Passende Sekundärantikörper)
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Klon
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LAT-1D1
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Beschreibung
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LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembraneadaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. Afterimmunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, orTec-family kinases, providing docking sites for downstream signaling molecules. LAT isessential for TCR-dependent T cell- and FcεRI-dependent mast cell activation, as well as formaturation of early thymocytes. It is also involved in NK cell signaling and plateletactivation.
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Spezifität
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The antibody LAT-1D1 reacts with mouse and rat Linker for activation of T cells (LAT), atransmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells andplatelets. Negative Species: HumanSpecies: Mouse, Rat. Others not tested.
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Applikationshinweise
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Western Blotting: 5-10 μg/mlPositive control: mouse spleen. Immunoprecipitation. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Konzentration
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1.0 mg/ml
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Reinigung
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Aff - Purified
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Buffer
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PBS, pH 7.4 with 15 mM sodium azide as preservative
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Lagerung
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Forschungsgebiet
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Signaltransduktion, Adaptive Immunität
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Linker For Activation of T Cells (LAT)", Typ "Antikörper" finden
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Wirte
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Maus (40), Kaninchen (22), Ziege (6)
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Reaktivitäten
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Human (64), Maus (16), Ratte (Rattus) (12)
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Applikationen
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Western Blot (WB) (47), Immunpräzipitation (IP) (20), Durchflusszytometrie (FACS) (18), Immunhistochemie (Paraffinschnitte) (IHC (p)) (12), ELISA (9), Enzyme Immunoassay (EIA) (8), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (5), Immunhistochemie (IHC) (3), Immunzytochemie (ICC) (2), Immunfluoreszenz (IF) (2), Dot Blot (Dot) (1)
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Konjugate
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APC (4), PE (4), Alexa Fluor 488 (1), Alexa Fluor 700 (1), DY647 (1)
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Epitope
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pTyr191 (2), pTyr132 (1)
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