Intercellular Adhesion Molecule 1 (ICAM1) Antikörper (Biotin)

Antigen: Intercellular Adhesion Molecule 1 (ICAM1)

Synonyme: BB2, CD54, P3.58, Ly-47, Icam-1, MALA-2, MGC6195, ICAM-1, ICAM1, ICAM

Klonalität: Monoklonal (15-Feb)

Wirt: Maus

Reaktivität: Human

Konjugat: Biotin

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN234691

Produktbeschreibung

Weitere Bezeichnung: CD54

Immunogen: Rheumatoid synovial cells and human monocytes

Format: Liquid

Isotyp: IgG1

Klon: 15-Feb

Beschreibung: MAb to CD54 ICAM-1 Monoclonal Antibody to CD54 Biotin conjugated

Spezifität: Recognizes the (Mr 85-115kDa) intercellular adhesion molecule ICAM-1 which permits antigen-independent adhesion between lymphocytes and their targets. The LFA-1 binding site is located in domain 1 of ICAM-1. ICAM-1 is a membrane glycoprotein with a wide tissue distribution that includes vascular endothelium and many cells of the immune system. CD54 is weakly expressed on resting peripheral blood lymphocytes. Upon activation by mitogens, the CD54 antigen is strongly expressed on B-cells, T-cells, macrophages and granulocytes. CD54 is the receptor for rhinoviruses and malaria

Anwendungen

Applikationshinweise: Anti-CD54 (ICAM-1) may be used to study cell-cell interactions. May also be used in studies of rhinovirus and malaria receptors. We recommend using 1ug to stain 1 x 106 cells in flow cytometric applications. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Konzentration: 100ug/ml (OD280nm)

Reinigung: Protein G chromatography

Buffer: 0.01M PBS, pH 7.2 containing 1% BSA. Preservative: 0.09% Sodium azide

Lagerung: Store at 2-8°C. DO NOT FREEZE.

Forschungsgebiet: CD Antigene, Oberflächenrezeptoren der Immunzellen , Immunologie, Inflammation, Infektionen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Berendt, McDowall, Craig et al.: "The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site." in: Cell, Vol. 68, Issue 1, pp. 71-81, 1992 (PubMed).