IKKA Antikörper

Antigen: IKKA

Klonalität: Monoklonal (3A11)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN234103

Produktbeschreibung

Immunogen: Synthetic peptide

Format: Liquid

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 3A11

Beschreibung: I kappa B kinase alpha (IKK alpha) is a component of a multiproteinkinase complex that regulates the activity of the transcription factorNF-kappa B. Activation of the IKK complex via upstream stimuli leads tophosphorylation and degradation of NF-kappaB bound I kappa B(Inhibitorof kappa B). Subsequently, free NF-kappaB dimers enter the nucleus andregulate the transcription of a variety of target genes involved in cellproliferation and differentiation, apoptosis, and inflammation, etc. The IKKcomplex consists of 2 highly homologous kinase subunits, IKK alpha andIKK beta, and a nonenzymatic regulatory component, IKK gamma/NEMO.The relative contributions of IKK alpha and IKK beta to the signalingcomplex vary according to the requirements of the cell. IKK beta plays apredominant role in immune responses, while IKK alpha alone appears tobe sufficient for at least some developmental systems. Recently,IKK/NF-kappa B signaling pathway was studied as therapeutic targets incancer.

Anwendungen

Applikationshinweise: WB (1:1,000)IP (1ul). Positive Control: HeLa.

Buffer: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50%glycerol

Lagerung: Store for 1 year at -20 degree from date of shipment

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-IKKA antibody