MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1)

Details for Product anti-MAPK8IP1 Antibody No. ABIN223343, Anbieter: Anmelden zum Anzeigen
Antigen
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
Reaktivität
Human, Maus, Ratte (Rattus)
66
47
39
Wirt
Kaninchen
71
2
1
Klonalität
Polyklonal
Konjugat
Dieser MAPK8IP1 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
58
31
17
13
9
7
4
3
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Synthetic peptide from mouse JIP1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN412803.
Isotyp IgG
Spezifität The antibody recognizes 78 kDa JIP1 in samples from mouse, rat and human origins.
Reactivity to other species has not been tested.
Reinigung Affinity purified
Andere Bezeichnung JIP1 (MAPK8IP1 Antibody Abstract)
Hintergrund JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.
Synonyms: JIP 1 , JNK , IB1 , IB 1 , MAPK8IP 1 , MAPK8IP1 , Mitogen activated protein kinase 8 ,
Gen-ID 19099
UniProt Q9WVI9
Applikationshinweise Western blotting (0.5-4 μg/mL). However, the optimal concentrations should be determined individually. The antibody recognizes 78 kDa JIP1 in samples from mouse, rat and human origins. In human sample, a ~110 kDa isoform can also be observed. Reactivity to other species has not been tested.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) protein A purified rabbit anti-JIP1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal.
Konservierungsmittel Thimerosal (Merthiolate)
Vorsichtsmaßnahmen This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody solution should be gently mixed before use.
Lagerung -20 °C
Informationen zur Lagerung For long-term storage, aliquot and freeze at -70 °C.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) antibody (ABIN223343) Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2...
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