Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (active) Antikörper

Antigen: Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3)

Synonyme: CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788, casp3, xcpp32, CASP3

Epitope: active

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN222873

Produktbeschreibung

Weitere Bezeichnung: Caspase-3 (Active)

Gen-ID: 836

Immunogen: Synthetic peptide mapping to the N-terminus adjacent to the cleavage site of human caspase-3

Format: Affinity-purified

Beschreibung: 100 ug affinity purified rabbit polyclonal antibody. Preferentially recognizes active human/mouse/rat caspase-3 (p20 subunits) and does not detect the precursor form. Performs well in Western blot and immunohistochemistry. Synonyms: Caspase-3 Polyclonal Ab, Anti-Caspase-3 polyclonal antibody, Caspase-3, Active caspase-3, caspase-3 antibody, caspase-3, anti-caspase-3, PARP, DEVD, cleaved caspase-3, active caspase-3 Synonyms: Caspase-3 Polyclonal Ab, Anti-Caspase-3 polyclonal antibody, Caspase-3, Active caspase-3, caspase-3 antibody, caspase-3, anti-caspase-3, PARP, DEVD, cleaved caspase-3, active caspase-3

Spezifität: Preferentially recognizes active human/mouse/rat caspase-3 (p20 subunits) and does not detect the precursor form

Synonyme: CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788, casp3, xcpp32, CASP3

Anwendungen

Applikationshinweise: The antibody can be used for Western blotting (0.5-4 ug/ml) and immunohistochemistry (10- 20 ug/ml). However, the optimal concentrations should be determined individually.

Buffer: 100 ug (0.2 mg/ml) affinity purified rabbit anti-Active Caspase-3 antibody in phosphate- buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.

Lagerung: Store at -20 o C. For long term storage, aliquot and freeze at

Forschungsgebiet: Apoptose/Nekrose

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blot analysis of caspase-3 in camptothecin (2 uM) treated Jurkat cells

Publikationen

Publikationen: Fernando, Kelly, Balazsi et al.: "Caspase 3 activity is required for skeletal muscle differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 17, pp. 11025-30, 2002 (PubMed).

Wang, Ladrech, Pujol et al.: "Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss." in: Cancer research, Vol. 64, Issue 24, pp. 9217-24, 2004 (PubMed).

Engelhardt, Smith, Fodor: "Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II." in: Journal of virology, Vol. 79, Issue 9, pp. 5812-8, 2005 (PubMed).

Fernando, Brunette, Megeney: "Neural stem cell differentiation is dependent upon endogenous caspase 3 activity." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 12, pp. 1671-3, 2005 (PubMed).

Schmidt, Paes, De Maziere et al.: "EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution." in: Development (Cambridge, England), Vol. 134, Issue 16, pp. 2913-23, 2007 (PubMed).

Frost, Zhou, Krasnesky et al.: "Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway." in: Neurochemical research, Vol. 34, Issue 1, pp. 169-81, 2009 (PubMed).

Guo, Tang, Li et al.: "[The analysis of the treatment of giant cell tumor of the pelvis and sacrum]" in: Zhonghua wai ke za zhi [Chinese journal of surgery], Vol. 46, Issue 7, pp. 501-5, 2008 (PubMed).

Mendoza-Rodruiguez, Martuinez, Vargas et al.: "Mating modifies apoptosis pattern in epithelial cells of the rat uterus." in: Molecular reproduction and development, Vol. 76, Issue 6, pp. 564-72, 2009 (PubMed).

Ou, Lee, Lee et al.: "Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 106, Issue 5, pp. 1674-85, 2009 (PubMed).

Chang, Hsieh, Peng et al.: "Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats." in: Journal of biomedical science, Vol. 16, pp. 9, 2009 (PubMed).

Roy, Krishna: "Evidence of androgen-dependent sperm storage in female reproductive tract of Scotophilus heathi." in: General and comparative endocrinology, Vol. 165, Issue 1, pp. 120-6, 2009 (PubMed).

Ueda, Ueyama, Oka et al.: "Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection." in: Journal of pharmacological sciences, Vol. 110, Issue 3, pp. 285-94, 2009 (PubMed).

Krejbich-Trotot, Denizot, Hoarau et al.: "Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 1, pp. 314-25, 2011 (PubMed).

Wu, Chen, Yen et al.: "Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2011, pp. 803015, 2010 (PubMed).

Finnie, Blumbergs, Manavis: "Aquaporin-4 expression after experimental contusional injury in an ovine impact-acceleration head injury model." in: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Vol. 18, Issue 7, pp. 947-50, 2011 (PubMed).