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TNFRSF1A Antikörper

TNFRSF1A Reaktivität: Maus WB, FACS, IP, Func, IA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2192161
  • Target Alle TNFRSF1A Antikörper anzeigen
    TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
    Reaktivität
    • 144
    • 84
    • 46
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 124
    • 41
    • 9
    • 9
    • 3
    • 2
    • 1
    Kaninchen
    Klonalität
    • 129
    • 59
    Polyklonal
    Konjugat
    • 91
    • 23
    • 19
    • 13
    • 9
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TNFRSF1A Antikörper ist unkonjugiert
    Applikation
    • 132
    • 87
    • 67
    • 62
    • 50
    • 30
    • 23
    • 22
    • 21
    • 18
    • 13
    • 12
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func), Immunoassay (IA)
    Kreuzreaktivität (Details)
    Cross reactivity: Mouse TNF-RII : Yes, Mouse TNF-alpha Minimal crossreactivity problematic in case of TNF-RI knockout studies and when used in high concentrations in functional studies
    Sterilität
    0.2 μm filtered
    Isotyp
    IgG
    Top Product
    Discover our top product TNFRSF1A Primärantikörper
  • Applikationshinweise
    For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Antibody reactivity with cell bound or soluble TNF-RI is not inhibited by high concentrations of mouse TNFα.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Gerspach, Götz, Zimmermann, Kolle, Böttinger, Grell: "Detection of membrane-bound tumor necrosis factor (TNF): an analysis of TNF-specific reagents." in: Microscopy research and technique, Vol. 50, Issue 3, pp. 243-50, (2000) (PubMed).

    Lucas, Garcia, Donati, Hribar, Mandriota, Giroud, Buurman, Fransen, Suter, Nunez, Pepper, Grau: "Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells." in: European journal of immunology, Vol. 28, Issue 11, pp. 3577-86, (1998) (PubMed).

    Bemelmans, Gouma, Buurman: "LPS-induced sTNF-receptor release in vivo in a murine model. Investigation of the role of tumor necrosis factor, IL-1, leukemia inhibiting factor, and IFN-gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 10, pp. 5554-62, (1993) (PubMed).

  • Target
    TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
    Andere Bezeichnung
    Cd120a, Tnf-Ri (TNFRSF1A Produkte)
    Synonyme
    CD120a antikoerper, FPF antikoerper, MS5 antikoerper, TBP1 antikoerper, TNF-R antikoerper, TNF-R-I antikoerper, TNF-R55 antikoerper, TNFAR antikoerper, TNFR1 antikoerper, TNFR1-d2 antikoerper, TNFR55 antikoerper, TNFR60 antikoerper, p55 antikoerper, p55-R antikoerper, p60 antikoerper, TNF-R1 antikoerper, TNF-alphaR1 antikoerper, TNFRI antikoerper, TNFRp55 antikoerper, TNFalpha-R1 antikoerper, Tnfr-2 antikoerper, Tnfr1 antikoerper, fpf antikoerper, tbp1 antikoerper, p55-r antikoerper, tnf-r antikoerper, tnfar antikoerper, tnfr1 antikoerper, cd120a antikoerper, tnfr55 antikoerper, tnfr60 antikoerper, xtnfr1 antikoerper, wu:fj65b10 antikoerper, zgc:85914 antikoerper, TNFR I antikoerper, TNFRSF1A antikoerper, TNFA antikoerper, cTNF antikoerper, TNF receptor superfamily member 1A antikoerper, tumor necrosis factor receptor superfamily, member 1a antikoerper, TNF receptor superfamily member 1A S homeolog antikoerper, tumor necrosis factor antikoerper, TNFRSF1A antikoerper, Tnfrsf1a antikoerper, tnfrsf1a.S antikoerper, tnfrsf1a antikoerper, TNF antikoerper
    Hintergrund
    The polyclonal antibody recognizes the extracellular part of the mouse Tumor Necrosis Factor Receptor type 1 (TNF-RI) of the membrane-bound as well as the soluble receptor. TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-RI-deficient mice indicate that TNF-RI mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways. Aliases Tumor necrosis factor receptor superfamily member 1A, TNF-RI, p55/p60
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Hepatitis C, Ubiquitin Proteasome Pathway
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