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CD46 Antikörper (FITC)

CD46 Reaktivität: Human WB, FACS Wirt: Maus Monoclonal M177 FITC
Produktnummer ABIN2191980
  • Target Alle CD46 Antikörper anzeigen
    CD46
    Reaktivität
    • 119
    • 39
    • 20
    • 10
    • 10
    • 1
    Human
    Wirt
    • 85
    • 54
    • 2
    Maus
    Klonalität
    • 73
    • 68
    Monoklonal
    Konjugat
    • 54
    • 17
    • 16
    • 9
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD46 Antikörper ist konjugiert mit FITC
    Applikation
    • 91
    • 81
    • 43
    • 40
    • 33
    • 19
    • 14
    • 14
    • 14
    • 10
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Sterilität
    0.2 μm filtered
    Klon
    M177
    Top Product
    Discover our top product CD46 Primärantikörper
  • Applikationshinweise
    For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive CD46 is expressed on every cell and tissue control Negative Erythrocytes control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Matsui, Sakurai, Katayama, Kurachi, Tashiro, Sugio, Kawabata, Mizuguchi: "Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob." in: Virus research, Vol. 155, Issue 1, pp. 48-54, (2010) (PubMed).

    Kato, Ohgimoto, Sharma, Kurazono, Ayata, Komase, Takeda, Takeuchi, Ihara, Ogura: "Reduced ability of hemagglutinin of the CAM-70 measles virus vaccine strain to use receptors CD46 and SLAM." in: Vaccine, Vol. 27, Issue 29, pp. 3838-48, (2009) (PubMed).

    Loré, Adams, Havenga, Precopio, Holterman, Goudsmit, Koup: "Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 3, pp. 1721-9, (2007) (PubMed).

    Kurita-Taniguchi, Hazeki, Murabayashi, Fukui, Tsuji, Matsumoto, Toyoshima, Seya: "Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF." in: Molecular immunology, Vol. 38, Issue 9, pp. 689-700, (2002) (PubMed).

    Iwata, Seya, Yanagi, Pesando, Johnson, Okabe, Ueda, Ariga, Nagasawa: "Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 15148-52, (1995) (PubMed).

    Seya, Hara, Matsumoto, Akedo: "Quantitative analysis of membrane cofactor protein (MCP) of complement. High expression of MCP on human leukemia cell lines, which is down-regulated during cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 1, pp. 238-45, (1990) (PubMed).

  • Target
    CD46
    Andere Bezeichnung
    Cd46, Membrane Cofactor Protein (CD46 Produkte)
    Synonyme
    AHUS2 antikoerper, MCP antikoerper, MIC10 antikoerper, TLX antikoerper, TRA2.10 antikoerper, Mcp antikoerper, CD46 antikoerper, CD46 molecule antikoerper, CD46 antigen, complement regulatory protein antikoerper, CD46 molecule, complement regulatory protein antikoerper, membrane cofactor protein-like antikoerper, CD46 antikoerper, Cd46 antikoerper, LOC100341359 antikoerper, LOC103789310 antikoerper
    Hintergrund
    The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain Aliases MCP, TLX, AHUS2, MIC10, TRA2.10, MGC26544, complement regulatory protein, trophoblast leucocyte common antigen Immunogen Purified MCP
    Pathways
    Regulation of Actin Filament Polymerization
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