IL1RN Antikörper

Produktnummer ABIN2191920

Produktdetails anti-IL1RN Antikörper

Target: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL1RN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Sterilität: 0.2 μm filtered

Klon: 2D11

Anwendungsinformationen

Applikationshinweise: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-IL1RN Antikörper (ABIN2191920)

Muzio, Polentarutti, Facchetti, Peri, Doni, Sironi, Transidico, Salmona, Introna, Mantovani: "Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra." in: European journal of immunology, Vol. 29, Issue 3, pp. 781-8, (1999) (PubMed).

Muzio, Polentarutti, Sironi, Poli, De Gioia, Introna, Mantovani, Colotta: "Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist." in: The Journal of experimental medicine, Vol. 182, Issue 2, pp. 623-8, (1995) (PubMed).

Details zu IL1RN

Target: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Andere Bezeichnung: Il-1ra3 (IL1RN Produkte)

Synonyme: DIRA antikoerper, ICIL-1RA antikoerper, IL-1RN antikoerper, IL-1ra antikoerper, IL-1ra3 antikoerper, IL1F3 antikoerper, IL1RA antikoerper, IRAP antikoerper, MVCD4 antikoerper, IRAP1 antikoerper, IL1RN antikoerper, IL-1RA antikoerper, F630041P17Rik antikoerper, interleukin 1 receptor antagonist antikoerper, interleukin 1 receptor antagonist-like antikoerper, IL1RN antikoerper, Il1rn antikoerper, IL1RNL antikoerper

Hintergrund: The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro- inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.

Pathways: NF-kappaB Signalweg, Hormone Transport, Cancer Immune Checkpoints