Dermcidin Antikörper

Produktnummer ABIN2191909

Produktdetails anti-Dermcidin Antikörper

Target: Dermcidin (DCD)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Dermcidin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)

Endotoxin-Niveau: Low endotoxin level

Klon: G-81

Anwendungsinformationen

Applikationshinweise: For immunohistology and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mL(> 200 μg/mL) culture medium with a low endotoxin level containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-Dermcidin Antikörper (ABIN2191909)

Minami, Uede, Sagawa, Kimura, Tsuji, Furukawa: "Immunohistochemical staining of cutaneous tumours with G-81, a monoclonal antibody to dermcidin." in: The British journal of dermatology, Vol. 151, Issue 1, pp. 165-9, (2004) (PubMed).

Sagawa, Kimura, Saito, Inoue, Yasuda, Nosaka, Tsuji: "Production and characterization of a monoclonal antibody for sweat-specific protein and its application for sweat identification." in: International journal of legal medicine, Vol. 117, Issue 2, pp. 90-5, (2003) (PubMed).

Details zu Dermcidin

Target: Dermcidin (DCD)

Andere Bezeichnung: Dermcidin (DCD Produkte)

Hintergrund: The monoclonal antibody G-81 recognizes a fragment of human dermcidin (DCD). The antibiotic peptide dermcidin (110 amino acids) is specifically and constitutively expressed in the sweat glands. DCD is localized to the dark mucous cells of normal eccrine sweat glands. DCD is normally expressed in eccrine sweat glands and is expressed in cutaneous mixed tumours. DCD-immunopositive cells are expressed in the inner cells of the tubular and ductal structures. The monoclonal antibody G-81 was produced against a sweat-specific antigen. It reacts to sweat but not to other body fluids (e.g. serum, saliva, semen, milk, urine and tears) in ELISA. The N-terminal amino acid sequence (18 amino acids residues) is identical to a part of human cachexia-associated protein and of a survival-promoting peptide for neuronal cells. Besides this, the sequence is identical to the C-terminal peptide (amino acids 62-79) of DCD. The monoclonal antibody G81 can be used as a specific marker for eccrine glands in the human skin. The monoclonal antibody G-81 is useful as a immunohistochemical tool to find the tumour cells that differentiate towards eccrine secretory cells in cutaneous mixed tumours. Furthermore, the antibody can be used for the detection of biochemical and histochemical changes of the sweat gland in the healing process of wound. Aliases AIDD, PIF, DSEP, HCAP, DCD-1 Immunogen Fractioned sweat peptides in complete Freund's adjuvant