Interferon gamma Antikörper

Produktnummer ABIN2191743

Produktdetails anti-Interferon gamma Antikörper

Target: Interferon gamma (IFNG)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Interferon gamma Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunoassay (IA), Inhibition Assay (InhA)

Klon: F3

Anwendungsinformationen

Applikationshinweise: For neutralisation of biological activity dilutions have to be made according to the amount of Interferon to be inactivated. One neutralizing unit is defined as the amount of antibody sufficient for neutralizing one unit of mouse gamma Interferon antiviral activity as calibrated against NIH standard Gg02-901-533.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute the vial by injection of 0.5 mLsterile distilled or de-ionized water (Caution: vial is under vacuum).

Buffer: Lyophilized product in PBS, containing 100 μg.

Handhabung: Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.

Lagerung: 4 °C

Informationen zur Lagerung: Lyophilized product should be stored at 4 °C Store stock solution in aliquots at -20 °C Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-Interferon gamma Antikörper (ABIN2191743)

Wolfs, Buurman, van Schadewijk, de Vries, Daemen, Hiemstra, van t Veer: "In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 3, pp. 1286-93, (2002) (PubMed).

Billiau, Heremans, Vandekerckhove, Dillen: "Anti-interferon-gamma antibody protects mice against the generalized Shwartzman reaction." in: European journal of immunology, Vol. 17, Issue 12, pp. 1851-4, (1988) (PubMed).

Dijkmans, Heremans, Billiau: "Heterogeneity of Chinese hamster ovary cell-produced recombinant murine interferon-gamma." in: The Journal of biological chemistry, Vol. 262, Issue 6, pp. 2528-35, (1987) (PubMed).

Heremans, Dijkmans, Sobis, Vandekerckhove, Billiau: "Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 138, Issue 12, pp. 4175-9, (1987) (PubMed).

Jacob, van der Meide, McDevitt: "In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon." in: The Journal of experimental medicine, Vol. 166, Issue 3, pp. 798-803, (1987) (PubMed).

van Tiel, Boere, Vinjé, Harmsen, Benaissa-Trouw, Kraaijeveld, Snippe: "Detection of Semliki Forest virus in cell culture by use of an enzyme immunoassay with peroxidase-labeled monoclonal antibodies specific for glycoproteins E1 and E2." in: Journal of clinical microbiology, Vol. 20, Issue 3, pp. 387-90, (1984) (PubMed).

Armstrong: "Semi-micro, dye-binding assay for rabbit interferon." in: Applied microbiology, Vol. 21, Issue 4, pp. 723-5, (1971) (PubMed).

Details zu Interferon gamma

Target: Interferon gamma (IFNG)

Andere Bezeichnung: gamma Interferon (IFNG Produkte)

Synonyme: IFG antikoerper, IFI antikoerper, IFN-g antikoerper, Ifg antikoerper, IFNG2 antikoerper, IFN-gamma antikoerper, IFN-G antikoerper, IFNG antikoerper, IFNgamma antikoerper, TCRalpha antikoerper, INF-G antikoerper, ifng antikoerper, interferon gamma antikoerper, interferon, gamma 1-2 antikoerper, IFNG antikoerper, Ifng antikoerper, ifng1-2 antikoerper

Hintergrund: Monoclonal antibody F3 binds and neutralizes both natural and recombinant mouse gamma Interferon. Its binding and neutralizing activity has been demonstrated in vitro and in vivo. F3 antibodies have been demonstrated to be able to inhibit inflammatory responses to bacterial lipopolysaccharides. These antibodies were furthermore shown to inhibit Shwartzman reactions and to protect NZB mice against spontaneous development of autoimmune disease. The antibody does not react with rat or human gamma interferon.

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie