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HCST Antikörper (AA 19-48) (Alexa Fluor 350)

HCST Reaktivität: Human, Ratte WB, FACS, IF (p), IF (cc) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN2175292
  • Target Alle HCST Antikörper anzeigen
    HCST (Hematopoietic Cell Signal Transducer (HCST))
    Bindungsspezifität
    AA 19-48
    Reaktivität
    Human, Ratte
    Wirt
    • 15
    Kaninchen
    Klonalität
    • 15
    Polyklonal
    Konjugat
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HCST Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 15
    • 13
    • 12
    • 12
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Human, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HCST
    Isotyp
    IgG
    Top Product
    Discover our top product HCST Primärantikörper
  • Applikationshinweise
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    HCST (Hematopoietic Cell Signal Transducer (HCST))
    Andere Bezeichnung
    Hcst (HCST Produkte)
    Synonyme
    DAP10 antikoerper, KAP10 antikoerper, PIK3AP antikoerper, Dap10 antikoerper, HCST antikoerper, dap10 antikoerper, dap10-A antikoerper, hcst antikoerper, hcsta antikoerper, kap10 antikoerper, pik3ap antikoerper, hematopoietic cell signal transducer antikoerper, hematopoietic cell signal transducer L homeolog antikoerper, HCST antikoerper, Hcst antikoerper, hcst antikoerper, hcst.L antikoerper
    Hintergrund

    Synonyms: DAP10, KAP10, PIK3AP, Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10, Transmembrane adapter protein KAP10, HCST, UNQ587/PRO1157

    Background: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs), these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.

    Gen-ID
    10870
    UniProt
    Q9UBK5
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