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FOXA2 Antikörper (AA 201-300) (PE)

FOXA2 Reaktivität: Human, Maus WB, FACS Wirt: Kaninchen Polyclonal PE
Produktnummer ABIN2174177
  • Target Alle FOXA2 Antikörper anzeigen
    FOXA2 (Forkhead Box A2 (FOXA2))
    Bindungsspezifität
    • 15
    • 14
    • 10
    • 10
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reaktivität
    • 91
    • 26
    • 15
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Human, Maus
    Wirt
    • 84
    • 8
    • 2
    Kaninchen
    Klonalität
    • 77
    • 17
    Polyklonal
    Konjugat
    • 48
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FOXA2 Antikörper ist konjugiert mit PE
    Applikation
    • 85
    • 50
    • 40
    • 25
    • 14
    • 14
    • 13
    • 10
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat,Cow,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HNF 3 beta
    Isotyp
    IgG
    Top Product
    Discover our top product FOXA2 Primärantikörper
  • Applikationshinweise
    FCM 1:20-100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Yamamizu, Schlessinger, Ko: "SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)." in: Development (Cambridge, England), Vol. 141, Issue 22, pp. 4254-66, (2014) (PubMed).

    Yamamizu, Fujihara, Tachibana, Katayama, Takahashi, Hara, Imai, Shinkai, Yamashita: "Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a." in: Cell stem cell, Vol. 10, Issue 6, pp. 759-70, (2012) (PubMed).

  • Target
    FOXA2 (Forkhead Box A2 (FOXA2))
    Andere Bezeichnung
    Foxa2/Hnf 3beta (FOXA2 Produkte)
    Synonyme
    hnf3b antikoerper, tcf3b antikoerper, hnf3beta antikoerper, hnf3-beta antikoerper, FOXA2 antikoerper, HNF3B antikoerper, TCF3B antikoerper, HNF-3B antikoerper, ax antikoerper, axl antikoerper, fkd1 antikoerper, ik:tdsubc_2g8 antikoerper, tdsubc_2g8 antikoerper, wu:fe05g04 antikoerper, xx:tdsubc_2g8 antikoerper, FoxA2-A antikoerper, FoxA2a antikoerper, xFD-3 antikoerper, xbeta-1 antikoerper, HNF-3b antikoerper, HNF3-beta antikoerper, HNF3beta antikoerper, Hnf-3b antikoerper, Hnf3b antikoerper, Tcf-3b antikoerper, Tcf3b antikoerper, HNF-3BETA antikoerper, forkhead box A2 antikoerper, forkhead box A2 L homeolog antikoerper, foxa2 antikoerper, FOXA2 antikoerper, foxa2.L antikoerper, Foxa2 antikoerper
    Hintergrund

    Synonyms: HNF3B, TCF3B, Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2

    Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs, FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

    Gen-ID
    3170
    UniProt
    Q9Y261
    Pathways
    Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process
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