Endoglin Antikörper (PE)

Produktnummer ABIN1981859

Produktdetails anti-Endoglin Antikörper (PE)

Target: Endoglin (ENG)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Endoglin Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: The rat monoclonal antibody MJ7/18 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.

Kreuzreaktivität (Details): Mouse

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Inflamed mouse skin

Klon: MJ7-18

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Kommentare:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-Endoglin Antikörper (PE) (ABIN1981859)

Dassler, Roohi, Lohrke, Ide, Remmele, Hütter, Pietsch, Pison, Schütz: "Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles." in: Investigative radiology, Vol. 47, Issue 7, pp. 383-91, (2012) (PubMed).

Rosu-Myles, She, Fair, Muradia, Mehic, Menendez, Prasad, Cyr: "Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells." in: PLoS ONE, Vol. 7, Issue 6, pp. e38954, (2012) (PubMed).

Fonsatti, Nicolay, Altomonte, Covre, Maio: "Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours." in: Cardiovascular research, Vol. 86, Issue 1, pp. 12-9, (2010) (PubMed).

Warrington, Hillarby, Li, Letarte, Kumar: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." in: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, (2005) (PubMed).

Herouet, Cottin, LeClaire, Enk, Rousset: "Contact sensitizers specifically increase MHC class II expression on murine immature dendritic cells." in: In vitro & molecular toxicology, Vol. 13, Issue 2, pp. 113-23, (2001) (PubMed).

Details zu Endoglin

Target: Endoglin (ENG)

Andere Bezeichnung: CD105 (ENG Produkte)

Synonyme: ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper

Hintergrund: Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG

Gen-ID: 13805

UniProt: Q63961