Merlin Antikörper (AA 516-520)

Produktnummer ABIN197520

Produktdetails anti-Merlin Antikörper

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Bindungsspezifität: AA 516-520

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Merlin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of total Merlin protein.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Immunogen: Peptide sequence around aa 516~520 (R-L-S-M-E) derived from Human Merlin

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500approx. 1/1000. Immunohistochemistry on Paraffin-Embedded Sections: 1/50approx. 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Andere Bezeichnung: Merlin (NF2 Produkte)

Synonyme: ACN antikoerper, BANF antikoerper, SCH antikoerper, NF2 antikoerper, merlin antikoerper, zgc:194620 antikoerper, zgc:194631 antikoerper, NF2a antikoerper, nf2 antikoerper, neurofibromin 2 antikoerper, neurofibromin 2a (merlin) antikoerper, neurofibromin 2b (merlin) antikoerper, neurofibromin 2 (merlin) S homeolog antikoerper, NF2 antikoerper, Nf2 antikoerper, nf2a antikoerper, nf2b antikoerper, nf2.S antikoerper

Hintergrund: Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.Synonyms: Moesin-ezrin-radixin-like protein, NF2, Neurofibromin-2, SCH, Schwannomerlin, Schwannomerlin, Schwannomin, Schwannomin

Gen-ID: 4771

NCBI Accession: NP_000259

UniProt: P35240

Pathways: Cell-Cell Junction Organization