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FAK Antikörper (Tyr925)

PTK2 Reaktivität: Human, Maus, Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN197349
  • Target Alle FAK (PTK2) Antikörper anzeigen
    FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
    Bindungsspezifität
    • 41
    • 29
    • 27
    • 25
    • 23
    • 23
    • 21
    • 18
    • 16
    • 16
    • 13
    • 11
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Tyr925
    Reaktivität
    • 335
    • 290
    • 225
    • 24
    • 21
    • 18
    • 17
    • 14
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 338
    • 27
    • 3
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 328
    • 44
    Polyklonal
    Konjugat
    • 185
    • 19
    • 16
    • 14
    • 14
    • 13
    • 13
    • 13
    • 13
    • 13
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    • 1
    Dieser FAK Antikörper ist unkonjugiert
    Applikation
    • 305
    • 126
    • 122
    • 121
    • 108
    • 75
    • 70
    • 52
    • 32
    • 31
    • 25
    • 6
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Antibody AP02673PU detects endogenous levels of total FAK protein.
    Aufreinigung
    Immunoaffinity Chromatography using epitope-specific immunogen.
    Immunogen
    The antiserum was produced against synthesized non-phosphopeptide derived from human FAK around the phosphorylation site of tyrosine 925 (K-V-Yp-E-N).
    Top Product
    Discover our top product PTK2 Primärantikörper
  • Applikationshinweise
    Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
    Andere Bezeichnung
    FAK1 / PTK2 (PTK2 Produkte)
    Synonyme
    FADK antikoerper, FAK antikoerper, FAK1 antikoerper, FRNK antikoerper, PPP1R71 antikoerper, p125FAK antikoerper, pp125FAK antikoerper, PTK2 antikoerper, Fadk antikoerper, mKIAA4203 antikoerper, fak antikoerper, fak1a antikoerper, ptk2 antikoerper, ptk2a antikoerper, wu:fa18c04 antikoerper, zgc:66114 antikoerper, CG10023 antikoerper, CT28129 antikoerper, DFAK antikoerper, DFak antikoerper, DFak56 antikoerper, Dfak antikoerper, Dfak56 antikoerper, DmFAK antikoerper, Dmel\\CG10023 antikoerper, Fak56 antikoerper, Fak56D antikoerper, fak56 antikoerper, protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2 L homeolog antikoerper, PTK2 protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2ab antikoerper, Focal adhesion kinase antikoerper, PTK2 antikoerper, ptk2.L antikoerper, Ptk2 antikoerper, ptk2ab antikoerper, Fak antikoerper
    Hintergrund
    Focal adhesion kinase (FAK) is a non receptor protein tyrosine kinase discovered as a substrate for Src and as a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion, however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly. FAK and its phosphorylation states have been implicated in cancer metastasis and tumor cell survival and adhesion-independent growth. Additionally, recent evidence indicates that elevation of FAK activity in human carcinoma cells is associated with increased invasive potential. A central role in tumor formation and progression suggests that FAK is an attractive target for therapeutic intervention.Synonyms: FADK1, FAK, Focal adhesion kinase 1, Protein-tyrosine kinase 2, pp125FAK
    Gen-ID
    5747
    NCBI Accession
    NP_722560
    UniProt
    Q05397
    Pathways
    Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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