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SHC1 Antikörper (pTyr349)

SHC1 Reaktivität: Human, Maus WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN197084
  • Target Alle SHC1 Antikörper anzeigen
    SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
    Bindungsspezifität
    • 28
    • 22
    • 20
    • 19
    • 12
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr349
    Reaktivität
    • 168
    • 127
    • 89
    • 12
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 152
    • 23
    Kaninchen
    Klonalität
    • 151
    • 24
    Polyklonal
    Konjugat
    • 80
    • 10
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    Dieser SHC1 Antikörper ist unkonjugiert
    Applikation
    • 150
    • 56
    • 38
    • 25
    • 20
    • 14
    • 14
    • 14
    • 13
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Spezifität
    This antibody detects endogenous levels of Shc1 only when phosphorylated at Tyrosine 349.
    Aufreinigung
    Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human Shc1 around the phosphorylation site of Tyrosine 349 (H-Q-Yp-Y-N).
    Top Product
    Discover our top product SHC1 Primärantikörper
  • Applikationshinweise
    Werstern Blot: 1/500approx. 1/1000. Immunofluorescence: 1/100-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
    Andere Bezeichnung
    SHC1 / SHC (SHC1 Produkte)
    Synonyme
    SHC1 antikoerper, SHC antikoerper, SHCA antikoerper, P66shc antikoerper, si:dkey-246i14.4 antikoerper, wu:fc10h03 antikoerper, shc antikoerper, p66shc antikoerper, Shc antikoerper, ShcA antikoerper, p66 antikoerper, SHC adaptor protein 1 antikoerper, Shc1p antikoerper, squalene--hopene cyclase antikoerper, SHC (Src homology 2 domain containing) transforming protein 1 antikoerper, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antikoerper, src homology 2 domain-containing transforming protein C1 antikoerper, SHC1 antikoerper, shc1 antikoerper, Shc1 antikoerper, shc1.L antikoerper
    Hintergrund
    The SHC gene encodes for a signaling and transforming protein containing Src homology 2 and 3 (SH2 and SH3) domains. The SHC gene encodes 2 widely expressed overlapping proteins of 46 and 52 kD, both containing a C-terminal SH2 domain. Adjacent to the SH2 region is a glycine and proline rich region. These 2 proteins differ in their N terminals. SHC proteins are involved in mitogenic signal transduction and act by coupling growth factor receptors to the RAS signaling pathway. The protein encoded by the SHC1 gene is thought to act as an adaptor in many signal transduction pathways.Synonyms: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, SHCA, Src homology 2 domain-containing-transforming protein C1
    Gen-ID
    6464
    NCBI Accession
    NP_001123512
    UniProt
    P29353
    Pathways
    RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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