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MTOR Antikörper (pSer2448)

mTOR Reaktivität: Human, Maus, Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN196963
  • Target Alle MTOR (mTOR) Antikörper anzeigen
    MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
    Bindungsspezifität
    • 34
    • 28
    • 23
    • 15
    • 12
    • 11
    • 9
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer2448
    Reaktivität
    • 214
    • 140
    • 121
    • 23
    • 17
    • 12
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 194
    • 16
    • 2
    • 2
    Kaninchen
    Klonalität
    • 174
    • 39
    Polyklonal
    Konjugat
    • 110
    • 11
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTOR Antikörper ist unkonjugiert
    Applikation
    • 148
    • 65
    • 63
    • 52
    • 52
    • 44
    • 36
    • 36
    • 17
    • 17
    • 12
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of mTOR only when phosphorylated at serine 2448.
    Aufreinigung
    Affinity Chromatography using epitope-specific phosphopeptide.
    Immunogen
    Synthesized phosphopeptide derived from human mTOR around the phosphorylation site of serine 2448 (T-D-SP-Y-S)
    Top Product
    Discover our top product mTOR Primärantikörper
  • Applikationshinweise
    Immunofluorescence: 1/100-1/200. Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
    Andere Bezeichnung
    mTOR / FRAP1 (mTOR Produkte)
    Synonyme
    FRAP1 antikoerper, FRAP antikoerper, FRAP2 antikoerper, RAFT1 antikoerper, RAPT1 antikoerper, 2610315D21Rik antikoerper, AI327068 antikoerper, Frap1 antikoerper, flat antikoerper, frap1 antikoerper, tor antikoerper, wu:fc22h08 antikoerper, mechanistic target of rapamycin kinase antikoerper, mechanistic target of rapamycin antikoerper, mechanistic target of rapamycin (serine/threonine kinase) antikoerper, MTOR antikoerper, Mtor antikoerper, mtor antikoerper
    Hintergrund
    MTOR, or FKBP12 rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289- kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.Synonyms: FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, FRAP, FRAP2, Mammalian target of rapamycin, RAPT1, Rapamycin target protein, Serine/threonine-protein kinase mTOR, TOR
    Molekulargewicht
    289 kDa (Predicted)
    Gen-ID
    2475
    NCBI Accession
    NP_004949
    UniProt
    P42345
    Pathways
    PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effekt
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