PRKDC Antikörper (pThr2609)

Produktnummer ABIN196899

Produktdetails anti-PRKDC Antikörper

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Bindungsspezifität: pThr2609

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKDC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: DNA PKcs (phospho-Thr2609) antibody detects endogenous levels of DNA PKcs only when phosphorylated at threonine 2609.

Aufreinigung: Immunoaffinity chromatography using epitope-specific phosphopeptide.

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human DNA PKcs around the phosphorylation site of threonine 2609 (V-E-TP-Q-A).

Anwendungsinformationen

Applikationshinweise: Suitable for use in Suitable for use in Western blot (1: 500-1: 1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu PRKDC

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Andere Bezeichnung: DNA-PKcs / PRKDC / XRCC7 (PRKDC Produkte)

Synonyme: DNA-PKcs antikoerper, DNAPK antikoerper, DNPK1 antikoerper, HYRC antikoerper, HYRC1 antikoerper, XRCC7 antikoerper, p350 antikoerper, DNA-PKCS antikoerper, dna-pkcs antikoerper, dnapk antikoerper, dnpk1 antikoerper, hyrc antikoerper, hyrc1 antikoerper, prkdc-A antikoerper, xrcc7 antikoerper, PRKDC antikoerper, AI326420 antikoerper, AU019811 antikoerper, DNAPDcs antikoerper, DOXNPH antikoerper, dxnph antikoerper, p460 antikoerper, scid antikoerper, slip antikoerper, protein kinase, DNA-activated, catalytic polypeptide antikoerper, protein kinase, DNA-activated, catalytic polypeptide L homeolog antikoerper, DNA-dependent protein kinase catalytic subunit antikoerper, protein kinase, DNA activated, catalytic polypeptide antikoerper, PRKDC antikoerper, prkdc.L antikoerper, LOC100633457 antikoerper, Prkdc antikoerper

Hintergrund: DNA PK is the key component of the non-homologous end-joining (NHEJ) pathway of DSB repair in mammalian cells. DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs). DNA PKcs is a serine/threonine protein kinase whose activity is greatly stimulated by its recruitment to DNA breaks by the Ku heterodimer.Synonyms: DNA-dependent protein kinase catalytic subunit, DNPK1, HYRC, HYRC1, p460

Gen-ID: 5591

NCBI Accession: NP_001075109

UniProt: P78527

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response