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MAP2K3 Antikörper (pSer189)

MAP2K3 Reaktivität: Human, Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN196863
  • Target Alle MAP2K3 Antikörper anzeigen
    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
    Bindungsspezifität
    • 25
    • 19
    • 15
    • 15
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer189
    Reaktivität
    • 141
    • 101
    • 81
    • 11
    • 10
    • 5
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 144
    • 12
    Kaninchen
    Klonalität
    • 130
    • 26
    Polyklonal
    Konjugat
    • 72
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Dieser MAP2K3 Antikörper ist unkonjugiert
    Applikation
    • 122
    • 49
    • 40
    • 39
    • 33
    • 28
    • 22
    • 9
    • 9
    • 8
    • 8
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    MKK3 (phospho-Ser189) antibody detects endogenous levels of MKK3 only when phosphorylated at serine189.
    Aufreinigung
    Immunoaffinity chromatography.
    Immunogen
    Synthetic phosphopeptide derived from human MKK3 around the phosphorylation site of serine 189 (V-D-SP-V-A).
    Top Product
    Discover our top product MAP2K3 Primärantikörper
  • Applikationshinweise
    Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
    Andere Bezeichnung
    MAP2K3 (MAP2K3 Produkte)
    Synonyme
    MAPKK3 antikoerper, MEK3 antikoerper, MKK3 antikoerper, PRKMK3 antikoerper, SAPKK-2 antikoerper, SAPKK2 antikoerper, AW212142 antikoerper, Prkmk3 antikoerper, mMKK3b antikoerper, Mkk3 antikoerper, mitogen-activated protein kinase kinase 3 antikoerper, mitogen activated protein kinase kinase 3 antikoerper, MAP kinase activator XMEK3 antikoerper, MAP2K3 antikoerper, Map2k3 antikoerper, map2k3 antikoerper
    Hintergrund
    MEK3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.Synonyms: Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MEK3, MKK3
    Gen-ID
    5606
    NCBI Accession
    NP_002747
    UniProt
    P46734
    Pathways
    MAPK Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling Events mediated by VEGFR1 and VEGFR2
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