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LIM Domain Kinase 1 Antikörper (pThr508)

LIMK1 Reaktivität: Human, Maus, Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN196830
  • Target Alle LIM Domain Kinase 1 (LIMK1) Antikörper anzeigen
    LIM Domain Kinase 1 (LIMK1)
    Bindungsspezifität
    • 24
    • 15
    • 15
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr508
    Reaktivität
    • 108
    • 82
    • 77
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 107
    • 16
    • 3
    Kaninchen
    Klonalität
    • 111
    • 15
    Polyklonal
    Konjugat
    • 54
    • 11
    • 9
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser LIM Domain Kinase 1 Antikörper ist unkonjugiert
    Applikation
    • 90
    • 56
    • 29
    • 26
    • 26
    • 19
    • 11
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of LIMK1 only when phosphorylated at Threonine 508.
    Aufreinigung
    Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human LIMK1 around the phosphorylation site of threonine 508 (R-Y-TP-V-V).
    Top Product
    Discover our top product LIMK1 Primärantikörper
  • Applikationshinweise
    Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1,0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    LIM Domain Kinase 1 (LIMK1)
    Andere Bezeichnung
    LIMK1 (LIMK1 Produkte)
    Synonyme
    limk1 antikoerper, xlimk1 antikoerper, GB16654 antikoerper, LIMK1 antikoerper, LIMK antikoerper, LIMK-1 antikoerper, LIM domain kinase 1 antikoerper, LIM domain kinase 1a antikoerper, LIM domain kinase 1 L homeolog antikoerper, LIM-domain containing, protein kinase antikoerper, LIMK1 antikoerper, limk1a antikoerper, limk1 antikoerper, CpipJ_CPIJ000717 antikoerper, LOC413152 antikoerper, Limk1 antikoerper, limk1.L antikoerper
    Hintergrund
    LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development, it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.Synonyms: EC=2.7.11.1, LIM domain kinase 1, LIMK, LIMK-1
    Gen-ID
    3984
    NCBI Accession
    NP_001191355
    UniProt
    P53667
    Pathways
    Caspase Kaskade in der Apoptose, Regulation of Cell Size, CXCR4-mediated Signaling Events
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