USP5 Antikörper

Produktnummer ABIN1944895

Produktdetails anti-USP5 Antikörper

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser USP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.

Klon: 1340CT704-170-140

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-USP5 Antikörper (ABIN1944895)

Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." in: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).

Details zu USP5

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Andere Bezeichnung: USP5 (USP5 Produkte)

Synonyme: ISOT antikoerper, AA407472 antikoerper, ISOT-1 antikoerper, Ucht antikoerper, ubiquitin specific peptidase 5 antikoerper, ubiquitin carboxyl-terminal hydrolase 5 antikoerper, ubiquitin carboxyl-terminal hydrolase 5, putative antikoerper, ubiquitin specific protease 5 antikoerper, ubiquitin specific peptidase 5 (isopeptidase T) antikoerper, USP5 antikoerper, CNH02890 antikoerper, EHI_049940 antikoerper, CC1G_12961 antikoerper, MCYG_01862 antikoerper, CGB_L3600C antikoerper, PY00546 antikoerper, Usp5 antikoerper

Hintergrund: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Molekulargewicht: 95786

Gen-ID: 8078

UniProt: P45974