Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
B
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ACVRL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 11-44amino acids from the N-terminal region of human ACVRL1.
ACVRL1
Reaktivität: Human
WB, ELISA
Wirt: Maus
Monoclonal
2C12
unconjugated
Applikationshinweise
WB: 1:1000. IHC-P: 1:25
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Berg, Gallione, Stenzel, Johnson, Allen, Schwartz, Jackson, Porteous, Marchuk: "The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2." in: American journal of human genetics, Vol. 61, Issue 1, pp. 60-7, (1997) (PubMed).
Target
ACVRL1
(Activin A Receptor Type II-Like 1 (ACVRL1))
ACVRL1 antikoerper, vgb antikoerper, alk1 antikoerper, zehn1109 antikoerper, hm:zehn1109 antikoerper, ACVRLK1 antikoerper, ALK-1 antikoerper, ALK1 antikoerper, HHT antikoerper, HHT2 antikoerper, ORW2 antikoerper, SKR3 antikoerper, TSR-I antikoerper, R-3 antikoerper, R3 antikoerper, SETHKIR antikoerper, AI115505 antikoerper, AI427544 antikoerper, Acvrlk1 antikoerper, Alk1 antikoerper, activin A receptor like type 1 antikoerper, activin A receptor type II-like 1 antikoerper, activin A receptor, type II-like 1 antikoerper, ACVRL1 antikoerper, acvrl1 antikoerper, Acvrl1 antikoerper
Hintergrund
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.