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beta-Catenin (CTNNB1) Antikörper

Antigen

beta-Catenin (CTNNB1)
Synonyme
CTNNB, FLJ25606, FLJ37923, DKFZp686D02253, Mesc, Catnb, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, ARM, Beta-cat, Beta-catenin, EG:86E4.6, beta-cat-arm, l(1)2Bv, l(1)G0192, l(1)G0234, l(1) ... mehr anzeigen
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human
Applikation
Alternativen Immunpräzipitation (IP), Western Blot (WB), Immunzytochemie (ICC)
Produktnummer ABIN192431
Menge 0.1 mg  (1 mg/ml)  (Varianten)
Preis 230,00 €   Zzgl. Versandkosten €40,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 3 bis 5 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper Varianten zurück nach oben

Weitere Bezeichnung beta-Catenin
Gen-ID 1499
Immunogen Bacterially expressed full-length human beta-catenin
Format Purified
Beschreibung Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation oftranscription. Calcium-dependent intercellular adhesion transmembrane glycoproteinE-cadherin interacts by its cytoplasmic domain with reciprocally bound alpha, beta andgamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton.Functional cadherin-catenin system is important for invasiveness of tumour cells.Beta-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 beta. Whenactivity of this kinase is blocked (e.g. by excessive stimulation of Wnt signaling pathway),hypophosphorylated stable form of beta-catenin accumulates in the cytoplasm, translocatesto the nucleus and activates transcription of genes including those that are involved in cellcycle control. As a result, cell division and neoplastic transformation are promoted.
Spezifität The polyclonal antibody reacts with beta-catenin, a 88 kDa multifunctional protein involvedboth in cell adhesion and in activation of transcription.
Synonyme CTNNB, FLJ25606, FLJ37923, DKFZp686D02253, Mesc, Catnb, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, ARM, Beta-cat, Beta-catenin, EG:86E4.6, beta-cat-arm, l(1)2Bv, l(1)G0192, l(1)G0234, l(1)G0410, l(1)arm, t12687 ALR Dm, DmelCG11579, CG11579, beta-catenin, ctnnb1, MGC79992, MGC132060, Cibeta-catenin, CTNNB1, MGC52601, LOC576711, Ctnnb1, MGC139922

Anwendungen
Alternativen Sekundärantikörper Varianten zurück nach oben

Applikationshinweise Immunoprecipitation - Positive control: DLD-1 human colon adenocarcinoma cell line. Application note: Reducing conditions. Immunocytochemistry - Recommended dilution: 1 µg/ml Staining technique: acetone / methanol fixation
Konzentration 1 mg/ml
Reinheit > 95% (by SDS-PAGE)
Reinigung Purified from rabbit serum by protein-A affinity chromatography.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Lagerung Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper Varianten zurück nach oben

Alternativen zu Antigen "beta-Catenin (CTNNB1)", Typ "Antikörper" finden
Wirte Kaninchen (186), Maus (62)
Reaktivitäten Human (230), Maus (155), Ratte (Rattus) (138), Huhn (29), Hund (13), Rind (Kuh) (8), Schwein (6), Xenopus laevis (5), Hamster (2), Affe (1), Kaninchen (1), Schaf (1)
Applikationen Western Blot (WB) (219), Immunfluoreszenz (IF) (72), Immunpräzipitation (IP) (62), Enzyme Immunoassay (EIA) (52), Immunhistochemie (Paraffinschnitte) (IHC (p)) (50), Immunhistochemie (IHC) (40), ELISA (30), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (20), Durchflusszytometrie (FACS) (19), Dot Blot (Dot) (8), Immunzytochemie (ICC) (4), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Elektromobilitäts-Experimente (EMSA) (1), Immunoelectron Microscopy (IEM) (1)
Konjugate Biotin (5), Cy3 (2), FITC (2), HRP (2), Alexa Flour 488 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1)
Epitope pSer33 (10), pSer37 (10), Ab-33 (5), Ab-37 (5), Ab-41/45 (5), C-Term (5), pSer33/37 (5), pThr41/Ser45 (5), pThr41/pSer45 (5), Ab-654 (3), pTyr654 (3), pTyr86 (3), exon 3 (2), pSer45 (2), Ab-489 (1), Core (1), dep27-37 (1), dep35-50 (1), pTyr489 (1)