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CD24 Antikörper (FITC)

CD24 Reaktivität: Human FACS Wirt: Maus Monoclonal SN3 FITC
Produktnummer ABIN192413
  • Target Alle CD24 Antikörper anzeigen
    CD24 (CD24 Molecule (CD24))
    Reaktivität
    • 82
    • 75
    • 36
    • 1
    Human
    Wirt
    • 52
    • 47
    • 40
    Maus
    Klonalität
    • 87
    • 51
    • 1
    Monoklonal
    Konjugat
    • 45
    • 11
    • 11
    • 11
    • 9
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD24 Antikörper ist konjugiert mit FITC
    Applikation
    • 96
    • 59
    • 27
    • 25
    • 19
    • 16
    • 14
    • 13
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Glycoproteins purified from human NALM-1 cell line.
    Klon
    SN3
    Isotyp
    IgG1
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." in: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).

    Maliar, Servais, Waks, Chmielewski, Lavy, Altevogt, Abken, Eshhar: "Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice." in: Gastroenterology, Vol. 143, Issue 5, pp. 1375-84.e1-5, (2012) (PubMed).

    Qiu, Low, Chang, Strohsnitter, Anderson, Edmiston, Adami, Ekbom, Hall, Lagiou, Trichopoulos, Hsieh: "Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 23, Issue 1, pp. 245-50, (2011) (PubMed).

    Solvason, Kearney: "The human fetal omentum: a site of B cell generation." in: The Journal of experimental medicine, Vol. 175, Issue 2, pp. 397-404, (1992) (PubMed).

    Fischer, Majdic, Gadd, Knapp: "Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 2, pp. 638-41, (1990) (PubMed).

    Barcos, Pollard, Fukukawa, Seon: "Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3." in: Hematological oncology, Vol. 4, Issue 4, pp. 251-9, (1987) (PubMed).

    Fukukawa, Matsuzaki, Haruta, Hara, Seon: "New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells." in: Experimental hematology, Vol. 14, Issue 9, pp. 850-5, (1986) (PubMed).

  • Target
    CD24 (CD24 Molecule (CD24))
    Andere Bezeichnung
    CD24 (CD24 Produkte)
    Synonyme
    CD24A antikoerper, Cd24a antikoerper, CD24 molecule antikoerper, CD24 antikoerper, Cd24 antikoerper
    Hintergrund
    CD24 Molecule,CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4, it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.,HSA, nectadorin, SCLC4
    Gen-ID
    100133941
    UniProt
    P25063
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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