Hsp70 Antikörper

Antigen: Hsp70

Synonyme: hspa1a, hsp70-4, CG31354, HSP70, Hsp70Bb, hsp70B, hsp70Bb-prime, DmelCG5834, CG5834, xhsp70, HSPA1, hsp70, Hsp70

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN191839

Produktbeschreibung

Produktmerkmale: Synonyms: Heat Shock Protein 70

Weitere Bezeichnung: Sponge Hsp70

Swiss-Prot: Q24952

Beschreibung: Heat shock proteins (HSPs) or stress response proteins (SRPs) are synthesized in variety ofenvironmental and pathophysiological stressful conditions. Many HSPs are involved inprocesses such as protein denaturation-renaturation, folding-unfolding,transport-translocation, activation-inactivation, and secretion. HSP70 is found to beassociated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and otherunknown proteins. Also, HSP70 has been shown to be involved in protective roles againstthermal stress, cytotoxic drugs, and other damaging conditions. Heat shock proteins are produced by prokaryotic and eukaryotic cells, and are among themost conserved molecules in phylogeny. Eukaryotic cells contain an HSP70 multigene thatdiffer in their intracellular location and regulation. Members of the HSP70 family play amajor role in the folding, unfolding and translocation of polypeptides as well as in theassembly and disassembly of oligomeric protein complexes, as well as in the immuneresponse. HSP72 was found to increase dramatically in the brains of Alzheimer’s diseasepatients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. HSP70 concentrates in nuclei during heat shock and returns to the cytoplasm when theshock is removed.

Spezifität: This antibody detects HSP70. Species: Geodia cydonium. Others not tested.

Anwendungen

Applikationshinweise: ELISA (1: 70,000). Western blot (1: 8,000). Immunohistochemistry (1: 1,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Reinigung: Serum

Lagerung: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing. Shelf life: One year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar