CCK-A Receptor (CCKAR) (AA 180-195) Antikörper

Antigen: CCK-A Receptor (CCKAR)

Synonyme: CCK-A, CCKRA, CCK1-R

Epitope: AA 180-195

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Produktnummer: ABIN191777

Produktbeschreibung

Produktmerkmale: Synonyms: CCKA Receptor, Cholecystokinin receptor type A, Cholecystokinin-1 receptor, CCKAR, CCKRA

Weitere Bezeichnung: CCK-A Receptor

Swiss-Prot: P32238

Immunogen: Synthetic human CCK-R Type A (aa 180-195) poly Lysin conjugatedAA Sequence: SNLVPFTKNNNQTANM

Kreuzreaktivität: Human

Beschreibung: The cholecystokinin (CCK) family of peptide hormones have been implicated in numerousimportant physiologic events. These appear to be mediated through 2 general classes ofreceptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin familypeptides. Through binding to class A receptors, CCK is a major physiologic mediator ofgallbladder contraction and pancreatic enzyme secretion. It appears to play a role inslowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulinsecretion. Further, it has been implicated as a mediator of pancreatic growth andtumorigenesis. Class A receptors have also been described in the anterior pituitary,myenteric plexus, and regions of the central nervous system, where they have beenimplicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia,and drug addiction.

Spezifität: This antibody detects CCK-R Type A (aa 180-195). Species: Human. Others not tested. Add. Information: LocusID 886

Anwendungen

Reinigung: Serum

Lagerung: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing. Shelf life: One year from despatch.

Forschungsgebiet: Hormone, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar