Apolipoprotein(a) / LP(a) (Oxidized) Antikörper

Antigen: Apolipoprotein(a) / LP(a) (Oxidized)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN191721

Produktbeschreibung

Produktmerkmale: Synonyms: Apo(a), LPA

Swiss-Prot: P08519

Immunogen: Human autooxidized Lipoprotein (a)Genename: LPA

Kreuzreaktivität: Human

Beschreibung: Lipoprotein (a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low densitylipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cellsthrough interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronaryheart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a)concentrations may be affected by disease states, but are only moderately affected by diet,exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a)concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but inadvanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulantrisk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen(PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface,reducing plasmin generation which increases clotting. This inhibition also promotesproliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in thegeneration of clots and atherosclerosis.

Spezifität: Fully oxidized modifications of LDL: Cu2+ oxidized LDL, MDA-LDL, HOCl-LDL, MDA-HSA,HOCl-HSA, HOCl-HDL. Native or minimally oxidized LDLSpecies: Human. Others not tested. Add. Information: LocusID 4018

Anwendungen

Applikationshinweise: ELISA and related methods (1/500-1/5.000). Immunohistochemistry on Paraffin Sections (< 1/500). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Reinigung: Serum

Lagerung: Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar