Mitofusin 1 (MFN1) Antikörper

Antigen: Mitofusin 1 (MFN1)

Synonyme: hfzo1, hfzo2, FLJ20693, MGC41806, DKFZp762F247, HR2, KIAA4032, mKIAA4032, D3Ertd265e, 2310002F04Rik, 6330416C07Rik, Fzo1b, MGC66150, zgc:66150, MFN1

Klonalität: Polyklonal

Wirt: Huhn

Reaktivität: Human, Maus

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Western Blot (WB)

Produktnummer: ABIN189718

Produktbeschreibung

Weitere Bezeichnung: Mitofusin-1

Gen-ID: 55669

Immunogen: A fusion protein against mouse MFN1, between residues 348-579.

Beschreibung: Mitochondrial fusion may regulate mitochondrial morphogenesis and underliecomplementation between mitochondrial genomes in mammalian cells. Mitochondrialdysfunction is a major cause of neuronal death in degenerative disorders, such asParkinson's disease, and can be triggered by an imbalance in the dynamic equilibriumbetween mitochondrial fission and fusion. Mfn1 (mitofusin 1) and Mfn2 (mitofusin 2) arenuclear encoded mitochondrial proteins. Mfn1 appears to be a key player in mediatingmitochondrial fusion and morphology in mammalian cells. Alternate Names: anti-Mitofusin 1 antibody, anti-Mfn1 antibody, anti-mouse homolog of Fuzzy OnionsFzo1 antibody. Related Diseases: Parkinson',s Disease

Spezifität: Species Reactivity: Reacts with human, mouse, and rat. Localization: Mitochondrion, mitochondrial outer membrane, multi-pass membrane protein (probable).

Anwendungen

Applikationshinweise: Suggested working dilutions: immunohistochemistry 1:50 - 1:400,Western Blot 1:1000. Positive Controls: Mouse embryonic fibroblast cell lysate.

Buffer: 100 mM Tris pH 8.0, 1% BSA. Preservative: 0.02% sodium azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Detection of MFN1 using ABIN189717.

Intracellular staining of Mitofusin-1 in neuronal cell body detected in sectioned human brain using ABIN189717.

Publikationen

Publikationen: Chen, Detmer, Ewald et al.: "Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 189-200, 2003 (PubMed).

Waxman, Kolliputi: "IL-6 Protects Against Hyperoxia Induced Mitochondrial Damage via BCL-2 induced BAK Interactions with Mitofusions." in: American journal of respiratory cell and molecular biology, 2009 (PubMed).