SYVN1 Antikörper (N-Term)

Produktnummer ABIN1882139

Produktdetails anti-SYVN1 Antikörper

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Bindungsspezifität: AA 58-88, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYVN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M, X

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).

Klon: RB5086

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SYVN1 Antikörper (ABIN1882139)

Smith, Granell, Salcedo-Sicilia, Baldini, Egea, Teckman, Baldini: "Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).

Klemm, Spooner, Ploegh: "Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37602-14, (2011) (PubMed).

Huang, Marvin, Tatsis, Eisenlohr: "Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 1904-8, (2011) (PubMed).

Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3525-34, (2004) (PubMed).

Amano, Yamasaki, Yagishita, Tsuchimochi, Shin, Kawahara, Aratani, Fujita, Zhang, Ikeda, Fujii, Miura, Komiya, Nishioka, Maruyama, Fukamizu, Nakajima: "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy." in: Genes & development, Vol. 17, Issue 19, pp. 2436-49, (2003) (PubMed).

Nadav, Shmueli, Barr, Gonen, Ciechanover, Reiss: "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1." in: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 91-7, (2003) (PubMed).

Details zu SYVN1

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Andere Bezeichnung: SYVN1 (HRD1) (SYVN1 Produkte)

Synonyme: DER3 antikoerper, HRD1 antikoerper, hrd1 antikoerper, 1200010C09Rik antikoerper, AW211966 antikoerper, C85322 antikoerper, D530017H19Rik antikoerper, Hrd1 antikoerper, RGD1310488 antikoerper, syvn1 antikoerper, syvn1-a antikoerper, syvn1-b antikoerper, wu:fk91f10 antikoerper, zgc:55735 antikoerper, zgc:77108 antikoerper, synoviolin 1 antikoerper, synovial apoptosis inhibitor 1, synoviolin antikoerper, synoviolin 1 S homeolog antikoerper, SYVN1 antikoerper, syvn1 antikoerper, Syvn1 antikoerper, syvn1.S antikoerper

Hintergrund: HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Molekulargewicht: 67685

NCBI Accession: NP_115807, NP_757385

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling