POLG2 Antikörper (C-Term)

Produktnummer ABIN1882118

Produktdetails anti-POLG2 Antikörper

Target: POLG2 (Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2))

Bindungsspezifität: AA 348-376, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This POLG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-376 amino acids from the C-terminal region of human POLG2.

Klon: RB17786

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-POLG2 Antikörper (ABIN1882118)

Haba, Hatakeyama, Kinoshita, Teramae, Azma, Hatano, Matsuda: "The modulation of vascular ATP-sensitive K+ channel function via the phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine." in: The Journal of pharmacology and experimental therapeutics, Vol. 334, Issue 2, pp. 673-8, (2010) (PubMed).

Longley, Clark, Yu Wai Man, Hudson, Durham, Taylor, Nightingale, Turnbull, Copeland, Chinnery: "Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia." in: American journal of human genetics, Vol. 78, Issue 6, pp. 1026-34, (2006) (PubMed).

Details zu POLG2

Target: POLG2 (Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2))

Andere Bezeichnung: POLG2 (POLG2 Produkte)

Synonyme: POLG2 antikoerper, im:7158733 antikoerper, si:ch211-157f15.3 antikoerper, HP55 antikoerper, MTPOLB antikoerper, PEOA4 antikoerper, POLB antikoerper, POLG-BETA antikoerper, POLGB antikoerper, mtpolb antikoerper, DNA polymerase gamma 2, accessory subunit antikoerper, polymerase (DNA directed), gamma 2, accessory subunit antikoerper, polymerase (DNA directed), gamma 2, accessory subunit L homeolog antikoerper, Polg2 antikoerper, POLG2 antikoerper, polg2 antikoerper, polg2.L antikoerper

Hintergrund: The accuracy of mitochondrial DNA (mtDNA) replication depends on the coordinated action of many nuclear-encoded proteins and on the correct balance of nucleotides within the mitochondrial matrix. mtDNA is replicated by DNA polymerase gamma, which is composed of a 140-kD catalytic subunit(POLG1) and a 55-kD accessory subunit (POLG2).

Molekulargewicht: 54911

NCBI Accession: NP_009146

UniProt: Q9UHN1