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MEK1 Antikörper (N-Term)

MAP2K1 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB3593 unconjugated
Produktnummer ABIN1882101
  • Target Alle MEK1 (MAP2K1) Antikörper anzeigen
    MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
    Bindungsspezifität
    • 46
    • 28
    • 28
    • 23
    • 22
    • 22
    • 20
    • 19
    • 18
    • 16
    • 15
    • 14
    • 11
    • 11
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reaktivität
    • 375
    • 205
    • 200
    • 37
    • 30
    • 18
    • 16
    • 12
    • 12
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 339
    • 33
    • 3
    • 2
    • 2
    Kaninchen
    Klonalität
    • 292
    • 87
    Polyklonal
    Konjugat
    • 180
    • 25
    • 22
    • 17
    • 15
    • 14
    • 14
    • 12
    • 12
    • 12
    • 12
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MEK1 Antikörper ist unkonjugiert
    Applikation
    • 246
    • 124
    • 103
    • 68
    • 66
    • 46
    • 33
    • 32
    • 25
    • 15
    • 11
    • 10
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Rb, Rat
    Aufreinigung
    This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This MEK1 (MAP2K1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).
    Klon
    RB3593
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MAP2K1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." in: Blood, Vol. 102, Issue 3, pp. 1019-27, (2003) (PubMed).

    Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).

    Zhu, Sun, Lee, Siedlak, Perry, Smith: "Distribution, levels, and activation of MEK1 in Alzheimer's disease." in: Journal of neurochemistry, Vol. 86, Issue 1, pp. 136-42, (2003) (PubMed).

    Fringer, Grinnell: "Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20612-7, (2003) (PubMed).

    Witowsky, Johnson: "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1403-6, (2003) (PubMed).

  • Target
    MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
    Andere Bezeichnung
    MEK1 (MAP2K1) (MAP2K1 Produkte)
    Synonyme
    Mek1 antikoerper, CFC3 antikoerper, MAPKK1 antikoerper, MEK1 antikoerper, MKK1 antikoerper, PRKMK1 antikoerper, MEKK1 antikoerper, Prkmk1 antikoerper, mek-2 antikoerper, si:ch211-242m18.2 antikoerper, wu:fj56a12 antikoerper, wu:fj61b01 antikoerper, zgc:56557 antikoerper, ATMEK1 antikoerper, F20B18.180 antikoerper, F20B18_180 antikoerper, MAP kinase/ ERK kinase 1 antikoerper, MITOGEN ACTIVATED PROTEIN KINASE KINASE antikoerper, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 antikoerper, NMAPKK antikoerper, MEK antikoerper, mitogen activated protein kinase kinase 1 antikoerper, mitogen-activated protein kinase kinase 1 antikoerper, mitogen-activated protein kinase kinase 1 L homeolog antikoerper, MAP kinase/ ERK kinase 1 antikoerper, Map2k1 antikoerper, MAP2K1 antikoerper, map2k1.L antikoerper, map2k1 antikoerper, MEK1 antikoerper
    Hintergrund
    MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
    Molekulargewicht
    43439
    NCBI Accession
    NP_002746
    UniProt
    Q02750
    Pathways
    MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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