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FAK Antikörper (N-Term)

PTK2 Reaktivität: Human WB Wirt: Maus Monoclonal 1297CT261-163-145 unconjugated
Produktnummer ABIN1882052
  • Target Alle FAK (PTK2) Antikörper anzeigen
    FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
    Bindungsspezifität
    • 41
    • 29
    • 27
    • 25
    • 23
    • 23
    • 21
    • 18
    • 16
    • 16
    • 13
    • 11
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-128, N-Term
    Reaktivität
    • 334
    • 290
    • 225
    • 24
    • 21
    • 18
    • 17
    • 14
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 338
    • 26
    • 3
    • 2
    • 1
    • 1
    Maus
    Klonalität
    • 328
    • 43
    Monoklonal
    Konjugat
    • 184
    • 19
    • 16
    • 14
    • 14
    • 13
    • 13
    • 13
    • 13
    • 13
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    • 1
    Dieser FAK Antikörper ist unkonjugiert
    Applikation
    • 304
    • 126
    • 122
    • 121
    • 108
    • 75
    • 70
    • 52
    • 32
    • 31
    • 25
    • 6
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This PTK2 antibody is generated from a mice immunized with a recombinant protein between 1-128 amino acids from the N-terminal region of human PTK2.
    Klon
    1297CT261-163-145
    Isotyp
    IgG1
    Top Product
    Discover our top product PTK2 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Nusbaum, Mikkelsen, Zody, Asakawa, Taudien, Garber, Kodira, Schueler, Shimizu, Whittaker, Chang, Cuomo, Dewar, FitzGerald, Yang, Allen, Anderson, Asakawa, Blechschmidt, Bloom, Borowsky, Butler, Cook et al.: "DNA sequence and analysis of human chromosome 8. ..." in: Nature, Vol. 439, Issue 7074, pp. 331-5, (2006) (PubMed).

    Whitney, Chan, Blake, Cosand, Neubauer, Aruffo, Kanner: "Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK." in: DNA and cell biology, Vol. 12, Issue 9, pp. 823-30, (1993) (PubMed).

    André, Becker-André: "Expression of an N-terminally truncated form of human focal adhesion kinase in brain." in: Biochemical and biophysical research communications, Vol. 190, Issue 1, pp. 140-7, (1993) (PubMed).

  • Target
    FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
    Andere Bezeichnung
    PTK2 (PTK2 Produkte)
    Synonyme
    FADK antikoerper, FAK antikoerper, FAK1 antikoerper, FRNK antikoerper, PPP1R71 antikoerper, p125FAK antikoerper, pp125FAK antikoerper, PTK2 antikoerper, Fadk antikoerper, mKIAA4203 antikoerper, fak antikoerper, fak1a antikoerper, ptk2 antikoerper, ptk2a antikoerper, wu:fa18c04 antikoerper, zgc:66114 antikoerper, CG10023 antikoerper, CT28129 antikoerper, DFAK antikoerper, DFak antikoerper, DFak56 antikoerper, Dfak antikoerper, Dfak56 antikoerper, DmFAK antikoerper, Dmel\\CG10023 antikoerper, Fak56 antikoerper, Fak56D antikoerper, fak56 antikoerper, protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2 L homeolog antikoerper, PTK2 protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2ab antikoerper, Focal adhesion kinase antikoerper, PTK2 antikoerper, ptk2.L antikoerper, Ptk2 antikoerper, ptk2ab antikoerper, Fak antikoerper
    Hintergrund
    Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation, required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1, most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1, GIT2 and SHC1, this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.
    Molekulargewicht
    119233
    UniProt
    Q05397
    Pathways
    Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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