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IKBKB Antikörper

IKBKB Reaktivität: Human WB Wirt: Maus Monoclonal 62AT992 unconjugated
Produktnummer ABIN1882049
  • Target Alle IKBKB Antikörper anzeigen
    IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
    Reaktivität
    • 284
    • 113
    • 72
    • 8
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Human
    Wirt
    • 289
    • 20
    • 1
    Maus
    Klonalität
    • 285
    • 25
    Monoklonal
    Konjugat
    • 133
    • 24
    • 24
    • 23
    • 18
    • 16
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    Dieser IKBKB Antikörper ist unkonjugiert
    Applikation
    • 160
    • 118
    • 107
    • 80
    • 80
    • 31
    • 29
    • 25
    • 22
    • 20
    • 15
    • 10
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta.
    Klon
    62AT992
    Isotyp
    IgG1
    Top Product
    Discover our top product IKBKB Primärantikörper
  • Applikationshinweise
    WB: 1:100~500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Tarantino, Tinevez, Crowell, Boisson, Henriques, Mhlanga, Agou, Israël, Laplantine: "TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures." in: The Journal of cell biology, Vol. 204, Issue 2, pp. 231-45, (2014) (PubMed).

    Sun, Wang, Zhao, Yu, Fan, Wang, Wang, Lu, Zhang, Fu, Yang: "Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21341-8, (2010) (PubMed).

    Potter, Cordell, Barton, Daly, Hyrich, Mann, Morgan, Wilson, Isaacs: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, (2010) (PubMed).

    Niida, Tanaka, Kamitani: "Downregulation of active IKK beta by Ro52-mediated autophagy." in: Molecular immunology, Vol. 47, Issue 14, pp. 2378-87, (2010) (PubMed).

    Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, (2010) (PubMed).

    Lobry, Lopez, Israël, Weil: "Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 3, pp. 908-13, (2007) (PubMed).

    Edwards: "Anticipation of disaster." in: Journal of the Royal Society of Medicine, Vol. 84, Issue 5, pp. 323, (1991) (PubMed).

  • Target
    IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
    Andere Bezeichnung
    IKK beta (IKBKB Produkte)
    Synonyme
    ikk-beta antikoerper, ikk2 antikoerper, ikkb antikoerper, ikkbeta antikoerper, IKBKB antikoerper, IKKB antikoerper, CG4201 antikoerper, DIK antikoerper, DLAK antikoerper, DmIKK antikoerper, DmIKKBeta antikoerper, DmIKKb antikoerper, DmIKKbeta antikoerper, DmIkkbeta antikoerper, Dmel\\CG4201 antikoerper, Dmikkb antikoerper, Dmikkbeta antikoerper, IK antikoerper, IKK antikoerper, IKK-beta antikoerper, IKKb antikoerper, IKKbeta antikoerper, IRD-5 antikoerper, IRD5 antikoerper, Ik antikoerper, Ikkb antikoerper, Ikkbeta antikoerper, Ird-5 antikoerper, Ird5 antikoerper, LRK antikoerper, Lak antikoerper, anon-89Bd antikoerper, dIKK antikoerper, dIKK-beta antikoerper, dIKKbeta antikoerper, dLak antikoerper, dmIKKbeta antikoerper, ikk antikoerper, ird antikoerper, ird5/DmIkk[beta] antikoerper, IKK2 antikoerper, NFKBIKB antikoerper, AIM-1 antikoerper, AI132552 antikoerper, IKK-2 antikoerper, IKK[b] antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antikoerper, inhibitor of nuclear factor kappa B kinase subunit beta antikoerper, I-kappaB kinase beta antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antikoerper, inhibitor of kappaB kinase beta antikoerper, ikbkb.L antikoerper, IKBKB antikoerper, ikbkb antikoerper, IKKbeta antikoerper, Ikbkb antikoerper
    Hintergrund
    NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
    Molekulargewicht
    86564
    NCBI Accession
    NP_001177649, NP_001229707, NP_001547
    UniProt
    O14920
    Pathways
    NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
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