STAT3 Antikörper (C-Term)

Produktnummer ABIN1881850

Produktdetails anti-STAT3 Antikörper

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Bindungsspezifität: AA 673-699, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, M, Pig, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This STAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-699 amino acids from the C-terminal region of human STAT3.

Klon: RB41075

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-STAT3 Antikörper (ABIN1881850)

Yin, Du, Cao, Liu, Xu, Xiang: "Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis." in: Digestive diseases and sciences, (2015) (PubMed).

Li, Cheung, Evans, Shaw: "Modulation of gene expression and tumor cell growth by redox modification of STAT3." in: Cancer research, Vol. 70, Issue 20, pp. 8222-32, (2010) (PubMed).

Takaishi, Komohara, Tashiro, Ohtake, Nakagawa, Katabuchi, Takeya: "Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation." in: Cancer science, Vol. 101, Issue 10, pp. 2128-36, (2010) (PubMed).

Li, Zou, Li: "Up-regulation of signal transducer and activator of transcription-3 is associated with aggravation of ulcerative colitis." in: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Vol. 8, Issue 5, pp. 262-6, (2010) (PubMed).

Schimke, Sawalle-Belohradsky, Roesler, Wollenberg, Rack, Borte, Rieber, Cremer, Maass, Dopfer, Reichenbach, Wahn, Hoenig, Jansson, Roesen-Wolff, Schaub, Seger, Hill, Ochs, Torgerson et al.: "Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis...." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 3, pp. 611-7.e1, (2010) (PubMed).

Iliopoulos, Jaeger, Hirsch, Bulyk, Struhl: "STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer." in: Molecular cell, Vol. 39, Issue 4, pp. 493-506, (2010) (PubMed).

Details zu STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Andere Bezeichnung: STAT3 (STAT3 Produkte)

Synonyme: 1110034C02Rik antikoerper, AW109958 antikoerper, Aprf antikoerper, APRF antikoerper, HIES antikoerper, Xstat3 antikoerper, aprf antikoerper, hies antikoerper, stat3 antikoerper, wu:fc15d02 antikoerper, wu:fl59g06 antikoerper, z-Stat3 antikoerper, signal transducer and activator of transcription 3 antikoerper, signal transduction and activation of transcription 3 antikoerper, signal transducer and activator of transcription 3, gene 1 L homeolog antikoerper, signal transducer and activator of transcription 3 (acute-phase response factor) antikoerper, STAT3 antikoerper, stat3 antikoerper, Stat3 antikoerper, stat3.1.L antikoerper

Hintergrund: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Molekulargewicht: 88068

NCBI Accession: NP_003141, NP_644805, NP_998827

UniProt: P40763

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor