SPIB Antikörper (C-Term)

Produktnummer ABIN1881823

Produktdetails anti-SPIB Antikörper

Target: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Bindungsspezifität: AA 216-245, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPIB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the C-terminal region of human SPIB.

Klon: RB40547

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SPIB Antikörper (ABIN1881823)

Liu, Invernizzi, Lu, Kosoy, Lu, Bianchi, Podda, Xu, Xie, Macciardi, Selmi, Lupoli, Shigeta, Ransom, Lleo, Lee, Mason, Myers, Peltekian, Ghent, Bernuzzi, Zuin, Rosina, Borghesio, Floreani et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, (2010) (PubMed).

Schmidlin, Diehl, Nagasawa, Scheeren, Schotte, Uittenbogaart, Spits, Blom: "Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression." in: Blood, Vol. 112, Issue 5, pp. 1804-12, (2008) (PubMed).

Nagasawa, Schmidlin, Hazekamp, Schotte, Blom: "Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B." in: European journal of immunology, Vol. 38, Issue 9, pp. 2389-400, (2008) (PubMed).

Dontje, Schotte, Cupedo, Nagasawa, Scheeren, Gimeno, Spits, Blom: "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B." in: Blood, Vol. 107, Issue 6, pp. 2446-52, (2006) (PubMed).

Geng, Vedeckis: "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter." in: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43264-71, (2005) (PubMed).

Details zu SPIB

Target: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Andere Bezeichnung: SPIB (SPIB Produkte)

Synonyme: spi-b antikoerper, spib antikoerper, spiba antikoerper, SPI-B antikoerper, B42b-like antikoerper, Spi-B antikoerper, Spi-B transcription factor L homeolog antikoerper, Spi-B transcription factor antikoerper, Spi-B transcription factor (Spi-1/PU.1 related) antikoerper, spib.L antikoerper, SPIB antikoerper, Spib antikoerper

Hintergrund: SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1, MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).

Molekulargewicht: 28819

NCBI Accession: NP_001230927, NP_001230928, NP_001230929, NP_003112

UniProt: Q01892